Tidal expiratory flow limitation and chronic dyspnoea in patients with cystic fibrosis
| Autor: | Y. Grossi, M. Bellet, D. Sarni, H. Ghezzo, J. Milic-Emili, C. Leroyer, D. Goetghebeur |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Spirometry medicine.medical_specialty Adolescent Cystic Fibrosis medicine.drug_class Sensitivity and Specificity Severity of Illness Index Statistics Nonparametric Airway resistance Functional residual capacity Internal medicine Bronchodilator Tidal Volume medicine Humans Lung volumes Prospective Studies Child Tidal volume Probability medicine.diagnostic_test business.industry Airway Resistance Forced Expiratory Flow Rates respiratory system Bronchodilator Agents respiratory tract diseases Surgery Expiratory Reserve Volume Dyspnea Chronic Disease Cardiology Salbutamol Female business medicine.drug |
| Zdroj: | European Respiratory Journal. 19:492-498 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.02.00220702 |
| Popis: | Cystic fibrosis (CF) eventually leads to hyperinflation linked to tidal expiratory flow limitation (FL) and ventilatory failure. Presence of FL was assessed at rest in 22 seated children and adults with CF (forced expiratory volume in one second (FEV1) range: 16-92% predicted), using both the negative expiratory pressure (NEP) technique and the "conventional" method based on comparison of tidal and maximal expiratory flow/volume curves. In addition, chronic dyspnoea was scored with the modified Medical Research Council (MRC) scale. Measurements were made before and 15 min after inhalation of salbutamol. With NEP, FL was present in only three malnourished patients, who had the lowest FEV1 values (16-27% pred) and claimed very severe dyspnoea (MRC score 5). By contrast, an additional seven patients were classified as FL with the conventional method. Six of these patients had little or no dyspnoea (MRC scores 0-1). Salbutamol administration had no effect on the extent of FL, and the concomitant decrease in functional residual capacity (FRC) was too small to play any clinically significant role. This study concluded that in seated patients with cystic fibrosis, expiratory flow limitation is absent at rest, unless the forced expiratory volume in one second is |
| Databáze: | OpenAIRE |
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