High expression FUT1 and B3GALT5 is an independent predictor of postoperative recurrence and survival in hepatocellular carcinoma

Autor: Chau-Ting Yeh, Jung-Tung Hung, Ming-Yi Ho, Yenlin Huang, Ruey-Jen Lin, John Yu, Chung-Bao Hsieh, Fei-Yun Lo, Alice L. Yu, Huan-Hsien Kuo, Tsai-Hsien Hung
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Pathology
lcsh:Medicine
Kaplan-Meier Estimate
Gastroenterology
0302 clinical medicine
80 and over
lcsh:Science
Cancer
Aged
80 and over
Multidisciplinary
Liver Disease
Liver Neoplasms
Middle Aged
Fucosyltransferases
Galactosyltransferases
Progression-Free Survival
Local
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Immunohistochemistry
Female
Stem cell
Liver Cancer
Adult
medicine.medical_specialty
Carcinoma
Hepatocellular
and over
Article
03 medical and health sciences
Rare Diseases
Internal medicine
medicine
Carcinoma
Humans
Progression-free survival
Survival analysis
Aged
business.industry
Proportional hazards model
lcsh:R
Hepatocellular
medicine.disease
030104 developmental biology
Neoplasm Recurrence
lcsh:Q
Neoplasm Recurrence
Local
Digestive Diseases
business
Zdroj: Scientific Reports
Scientific reports, vol 7, iss 1
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
ISSN: 2045-2322
Popis: Cancer may arise from dedifferentiation of mature cells or maturation-arrested stem cells. Previously we reported that definitive endoderm from which liver was derived, expressed Globo H, SSEA-3 and SSEA-4. In this study, we examined the expression of their biosynthetic enzymes, FUT1, FUT2, B3GALT5 and ST3GAL2, in 135 hepatocellular carcinoma (HCC) tissues by qRT-PCR. High expression of either FUT1 or B3GALT5 was significantly associated with advanced stages and poor outcome. Kaplan Meier survival analysis showed significantly shorter relapse-free survival (RFS) for those with high expression of either FUT1 or B3GALT5 (P = 0.024 and 0.001, respectively) and shorter overall survival (OS) for those with high expression of B3GALT5 (P = 0.017). Combination of FUT1 and B3GALT5 revealed that high expression of both genes had poorer RFS and OS than the others (P P P = 0.012) in HCC. In addition, the presence of Globo H, SSEA-3 and SSEA-4 in some HCC tissues and their absence in normal liver was established by immunohistochemistry staining and mass spectrometric analysis.
Databáze: OpenAIRE
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