Dual Mode of Action of Talaromyces purpureogenus CFRM02 Pigment to Ameliorate Alcohol Induced Liver Toxicity in Rats

Autor:	Saritha Gopal Pandit, Krishna Prashanth Ramesh Mekala, Mohankumari H. Puttananjaiah, Muthukumar Serva Peddha, Mohan Appasaheb Dhale
Rok vydání:	2022
Předmět:	Liver Talaromyces Hepatitis Alcoholic Hepatocytes Animals Bioengineering General Medicine Molecular Biology Applied Microbiology and Biotechnology Biochemistry Antioxidants Biotechnology Rats
Zdroj:	Applied biochemistry and biotechnology. 194(9)
ISSN:	1559-0291
Popis:	Talaromyces purpureogenus CFRM02 pigment exhibited antioxidant activity by scavenging free radicals. The alcohol feeding lead to free radical generation causing pathophysiological processes of alcoholic liver disease (ALD) and alcoholic hepatitis. The T. purpureogenus CFRM02 pigment administered to rats ameliorated the ALD by scavenging ROS. The haematological analysis revealed the increased neutrophil circulation. The neutrophil infiltration was observed in the hepatocytes of the rats fed with pigment (600 mg/kg body weight). The increase in number of neutrophils help in the liver regeneration caused by alcoholic hepatitis. The dual mechanism of action of pigment, antioxidant and liver regeneration through neutrophil production is attributed to alleviate the ALD. These results suggested T. purpureogenus CFRM02 pigment represents a novel protective and therapeutic strategy against ALD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f556e52dfccb6944e3a34870914f912 https://pubmed.ncbi.nlm.nih.gov/35587325 Zobrazit plný text záznamu Full text from SpringerLink