Time-course effects of aerobic interval training and detraining in patients with metabolic syndrome
| Autor: | V. Guio de Prada, Valentín E. Fernández-Elías, Juan F. Ortega, Nassim Hamouti, J. Cañete García-Prieto, Ignacio Ara, Amelia Guadalupe-Grau, María Martín-García, Ana Saborido, Vicente Martínez-Vizcaíno, Ricardo Mora-Rodriguez |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Time Factors Waist Endocrinology Diabetes and Metabolism Enfermedad cardiovascular Medicine (miscellaneous) Blood Pressure Resistencia a la insulina Interval training Body Mass Index chemistry.chemical_compound Insulin resistance High-density lipoprotein Internal medicine medicine Humans Aerobic exercise Exercise Triglycerides Metabolic Syndrome Nutrition and Dietetics Obesity therapy business.industry Ejercicio aerobico Cholesterol HDL Middle Aged medicine.disease Circumference Cardiovascular disease Adaptation Physiological Diet Exercise Therapy Mitochondria Terapia de obesidad Endocrinology Blood pressure chemistry Cardiology Female Waist Circumference Metabolic syndrome Cardiology and Cardiovascular Medicine business |
| Zdroj: | RUIdeRA. Repositorio Institucional de la UCLM instname |
| Popis: | Background and aims: Exercise training can improve health of patients with metabolic syndrome(MetS).However,whichMetS factors aremost responsive to exercise training remains unclear. We studied the time-course of changes in MetS factors in response to training and detraining. Methods and results: Forty eightMetS patients (52 8.8 yrs old; 33 4 BMI) underwent 4months (3 days/week) of supervised aerobic interval training (AIT) program. After 1 month of training, there were progressive increases in high density lipoprotein cholesterol (HDL-c) and reductions in waist circumference and blood pressure (12 3, 3.9 0.4, and 12 1%, respectively after 4 months; all P < 0.05). However, fasting plasma concentration of triglycerides and glucose were not reduced by training. Insulin sensitivity (HOMA), cardiorespiratory fitness (VO2peak) and exercisemaximal fat oxidation (FOMAx) also progressively improved with training ( 17 5; 21 2 and 31 8%, respectively, after 4months; all P < 0.05). Vastus lateralis samples fromseven subjects revealed that mitochondrial O2 flux was markedly increased with training (71 11%) due to increased mitochondrial content. After 1 month of detraining, the training-induced improvements in waist circumference and blood pressure were maintained. HDL-c and VO2peak returned to the values found after 1e2 months of training while HOMA and FOMAx returned to pre-training values. Conclusions: The health related variables most responsive to aerobic interval training in MetS patients arewaist circumference, blood pressure and the muscle and systemic adaptations to consume oxygen and fat. However, the latter reverse with detraining while blood pressure andwaist circumference are persistent to one month of detraining. |
| Databáze: | OpenAIRE |
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