Evaluating toxicity impacts of environmental exposed chromium on small Indian mongoose (Urva auropunctatus) hematological, biochemical and histopathological functioning
| Autor: | Shaista Andleeb, Sunil Kr. Jha, Shenxu Bao, Zulfiqar Ahmad, Abdullah Arif Saeed, Tariq Mahmood |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Chromium
Male medicine.medical_specialty Environmental Engineering Necrosis Herpestidae Health Toxicology and Mutagenesis 0208 environmental biotechnology Physiology 02 engineering and technology 010501 environmental sciences Kidney 01 natural sciences Nephrotoxicity Excretion medicine Environmental Chemistry Animals 0105 earth and related environmental sciences business.industry Public Health Environmental and Occupational Health General Medicine General Chemistry Pollution 020801 environmental engineering medicine.anatomical_structure Vacuolization Liver Toxicity Histopathology Environmental Pollutants Female medicine.symptom business Environmental Pollution Homeostasis |
| Zdroj: | Chemosphere. 259 |
| ISSN: | 1879-1298 |
| Popis: | Sub-lethal toxic impacts of chromium on hematological, biochemical and histological parameters were analyzed in the female small Indian mongoose (Urva auropuctatus) residing contaminated environment of tannery industry. Chromium bioaccumulation in the blood, liver and kidney tissue of the exposed mongooses was found elevated compared to the control mongooses' tissues. Total body weight (75.7%), liver weight (83.6%) as well as HSI (68.1%), RSI (86.2%) and the platelets counts (59.7%) were found significantly elevated, with significantly reduced RBCs (59.6%), and WBCs (64%). LFT and RFT were also found abnormal, moreover, the histopathological injuries had been distinct inside the kidney (>75%) and hepatic (>75%) tissues of exposed animals. Shrinkage and vacuolization (>75%) inside the hepatocyte expanded sinusoidal spaces and nuclear pyknosis (>75%) was evident within the hepatic tissue. Hypertrophy of epithelial cells of renal tubules and inter-renal cells of the head kidney with a reduction in tubular lumens (>75%) and vacuolization of tubules were witnessed within the kidney section. Atrophy inside the kidney inter-renal cells, glomeruli compression within the Bowman's capsules (>75%) following the necrosis in hematopoietic tissues were found in exposed animals. The present findings indicate that chronic exposure to chromium induces severe anemia, decreased serum protein concentration, hepatic and renal tissue histopathology, impairing the vital capabilities of liver, metabolic regulation, excretion, and stress homeostasis maintenance of which within the long-run may posture a severe risk to animal well-being then distress their inhabitants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect