Rotational dynamics reduce interference between sensory and memory representations
| Autor: | Alexandra Libby, Timothy J. Buschman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Computer science Models Neurological Population Sensory system Stimulus (physiology) Interference (wave propagation) Auditory cortex Article Mice 03 medical and health sciences Cognition 0302 clinical medicine Dimension (vector space) Memory Encoding (memory) Animals education Auditory Cortex Neurons education.field_of_study Quantitative Biology::Neurons and Cognition General Neuroscience Representation (systemics) Implicit learning Memory Short-Term 030104 developmental biology Transformation (function) Acoustic Stimulation Auditory Perception Neural coding Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature neuroscience |
| ISSN: | 1546-1726 1097-6256 |
| Popis: | Cognition depends on integrating sensory percepts with the memory of recent stimuli. However, the distributed nature of neural coding can lead to interference between sensory and memory representations. Here, we show the brain mitigates such interference by rotating sensory representations into orthogonal memory representations over time. To study how sensory inputs and memories are represented, we recorded from auditory cortex of mice as they implicitly learned sequences of sounds. We found the neural population represented sensory inputs and the memory of recent stimuli in two orthogonal dimensions. The transformation of sensory information into a memory was facilitated by a combination of ‘stable’ neurons, that maintained their selectivity over time, and ‘switching’ neurons, that inverted their selectivity over time. Together, these neural responses rotated the population representation, transforming sensory into memory. Theoretical modeling showed this rotational dynamic was an efficient mechanism for generating orthogonal representations, thereby protecting memories from sensory interference. One Sentence Summary: Sensory representations dynamically rotate into an orthogonal memory representation, reducing interference with new sensory inputs. |
| Databáze: | OpenAIRE |
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