Risk scoring system for predicting breast conservation after neoadjuvant chemotherapy
| Autor: | Emile Daraï, Jean Lévêque, Joseph Pilloy, Vincent Lavoué, Flavie Arbion, Gilles Body, Caroline Brisson, Sofiane Bendifallah, Lobna Ouldamer |
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| Rok vydání: | 2018 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Scoring system medicine.medical_treatment Breast Neoplasms Mastectomy Segmental Risk Assessment 030218 nuclear medicine & medical imaging 03 medical and health sciences Young Adult 0302 clinical medicine Breast cancer Internal medicine Internal Medicine medicine Humans Aged Aged 80 and over Chemotherapy Breast conservation Receiver operating characteristic Tumor size business.industry Patient Selection Area under the curve Reproducibility of Results Middle Aged medicine.disease Neoadjuvant Therapy Breast conservative surgery Logistic Models 030220 oncology & carcinogenesis Area Under Curve Surgery Female Neoplasm Recurrence Local business |
| Zdroj: | The breast journal. 25(4) |
| ISSN: | 1524-4741 |
| Popis: | We developed a risk scoring system (RSS) for predicting breast conservative surgery (BCS) in women receiving neoadjuvant chemotherapy(NAC) for breast cancer. BCS rate in the training set was 32.6%, associated with five variables: age < 50years, primary radiological tumor diameter < 60mm, absence of multifocality, absence of breast inflammation and hormone receptor status. These variables were assigned scores ranging from 0 to 9. The discrimination of the RSS was 0.78(95%CI 0.69-0.86) in the training set. The area under the curve of the receiver operating characteristics for predicting BCS after internal and external validation was 0.77(95%CI 0.68-0.85) and 0.75(95%CI 0.66-0.84), respectively. |
| Databáze: | OpenAIRE |
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