Effects of subthalamic nucleus deep brain stimulation on neuronal spiking activity in the substantia nigra pars compacta in a rat model of Parkinson’s disease
Autor: | Gianna Mamone, Emily Mahoney, Siddhartha Sahai, Zall Hirschstein, Benjamin J. Moolick, Kainat Akhtar, Heidi R. Tucker, Saisree Mikkilineni, Fu Yee Chua, Eric Molho, Julie G. Pilitsis, Megan Gupta, Alycia Nicholson, Emaan T. Effendi, Damian S. Shin |
---|---|
Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Levodopa Parkinson's disease Action Potentials Substantia nigra Stimulation Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Parkinsonian Disorders Subthalamic Nucleus Dopamine medicine Animals Premovement neuronal activity Pars Compacta Neurons Pars compacta business.industry General Neuroscience Parkinson Disease medicine.disease Electric Stimulation nervous system diseases Disease Models Animal surgical procedures operative 030104 developmental biology medicine.anatomical_structure nervous system Neuron business therapeutics Neuroscience 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Neuroscience Letters. 739:135443 |
ISSN: | 0304-3940 |
Popis: | Parkinson's Disease (PD) patients undergoing subthalamic nucleus deep brain stimulation (STN-DBS) therapy can reduce levodopa equivalent daily dose (LEDD) by approximately 50 %, leading to less symptoms of dyskinesia. The underlying mechanisms contributing to this reduction remain unclear, but studies posit that STN-DBS may increase striatal dopamine levels by exciting remaining dopaminergic cells in the substantia nigra pars compacta (SNc). Yet, no direct evidence has shown how SNc neuronal activity responds during STN-DBS in PD. Here, we use a hemiparkinsonian rat model of PD and employ in vivo electrophysiology to examine the effects of STN-DBS on SNc neuronal spiking activity. We found that 43 % of SNc neurons in naïve rats reduced their spiking frequency to 29.8 ± 18.5 % of baseline (p = 0.010). In hemiparkinsonian rats, a higher number of SNc neurons (88 % of recorded cells) decreased spiking frequency to 61.6 ± 4.4 % of baseline (p = 0.030). We also noted that 43 % of SNc neurons in naïve rats increased spiking frequency from 0.2 ± 0.0 Hz at baseline to 1.8 ± 0.3 Hz during stimulation, but only 1 SNc neuron from 1 hemiparkinsonian rat increased its spiking frequency by 12 % during STN-DBS. Overall, STN-DBS decreased spike frequency in the majority of recorded SNc neurons in a rat model of PD. Less homogenous responsiveness in directionality in SNc neurons during STN-DBS was seen in naive rats. Plausibly, poly-synaptic network signaling from STN-DBS may underlie these changes in SNc spike frequencies. |
Databáze: | OpenAIRE |
Externí odkaz: |