Spontaneous coronary artery dissection: Overview of pathophysiology
| Autor: | Domenico Gabrielli, Stefania Angela Di Fusco, Furio Colivicchi, Annamaria Iorio, Luigi Pollarolo, Roberta Rossini, Fortunato Scotto di Uccio, Michele Massimo Gulizia, Fabiana Lucà, Filippo Zilio |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Acute coronary syndrome business.industry Coronary Vessel Anomalies 030204 cardiovascular system & hematology Coronary Angiography medicine.disease Research findings Pathophysiology Clinical Practice 03 medical and health sciences 0302 clinical medicine Risk Factors medicine Humans Vascular Diseases 030212 general & internal medicine Cardiology and Cardiovascular Medicine Intensive care medicine Artery dissection Scad business |
| Zdroj: | Trends in Cardiovascular Medicine. 32:92-100 |
| ISSN: | 1050-1738 |
| DOI: | 10.1016/j.tcm.2021.01.002 |
| Popis: | The growing use of imaging examinations has led to increased detection of spontaneous coronary artery dissection (SCAD) as a non-atherosclerotic cause of acute coronary syndrome (ACS). Since a greater awareness of pathophysiologic mechanisms has relevant implications in clinical practice, we aim to provide an update to current knowledge of SCAD pathophysiology. We discuss the most common conditions associated with SCAD, including predisposing factors and triggers, and focus on potential mechanisms leading to SCAD development. Furthermore, we report the main genetic research findings that have shed further light on SCAD pathophysiology. Finally, we summarize practical considerations in SCAD management based on pathophysiologic insights. |
| Databáze: | OpenAIRE |
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