The platelet functions in patients with ankylosing spondylitis: Anti-TNF-αtherapy decreases the mean platelet volume and platelet mass

Autor: Selma Yazici, Safinaz Ataoglu, Hakan Özhan, Yalkın Çalik, Burak Erer, Mehmet Yazici, Serkan Bulur, Betül Erer
Rok vydání: 2010
Předmět:
Zdroj: Platelets. 21:126-131
ISSN: 1369-1635
0953-7104
DOI: 10.3109/09537100903470306
Popis: WOS: 000274880600007 PubMed: 20050759 The present study was designed to investigate the interaction between platelet indices (mean platelet volume (MPV), platelet count (PLC) and platelet mass (PLM)), inflammatory markers and disease activity in ankylosing spondylitis (AS) subjects. The effects of anti-TNF-alpha therapy and conventional treatment on platelet indices were also compared. We studied 68 patients with AS (group I, 46 men, age: 36.4 +/- 6.9 years) and as control group 34 age and sex-matched healty subjects. All patients received conventional therapy (CT) at the beginning (Group I). The patients were reevaluated after 3 months according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score. Group II consisted of 35 subjects who responded to the CT and continued to take the same therapy for 3 months additionally. Group III consisted of 33 subjects who had a high disease activity score (BASDAI > 4) after 3 months and were accepted refractory to the CT therapy. In Group III the treatment was switched to infliximab and continued for 3 months at the standard intravenous dose. Significantly higher baseline MPV, PLC and PLM was reported as compared to controls decreased by therapy (9.12 +/- 1.20 vs. 8.35 +/- 0.94 fl, p < 0.001, 340 +/- 69 vs. 251 +/- 56 (x10
Databáze: OpenAIRE
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