Role of the Suprachiasmatic and Arcuate Nuclei in Diurnal Temperature Regulation in the Rat
| Autor: | Oscar Daniel Ramirez-Plascencia, Arlen Ramirez-Corona, Mara A. Guzmán-Ruiz, MariCarmen Basualdo Sigales, Ruud M. Buijs, Natalí N. Guerrero-Vargas, Carolina Escobar, Elizabeth Sabath, Luis León-Mercado, Rebecca Fuentes-Romero |
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| Rok vydání: | 2015 |
| Předmět: |
Cholera Toxin
medicine.medical_specialty Microdialysis Biology Dorsal raphe nucleus Arcuate nucleus Internal medicine medicine Animals Melanocyte-Stimulating Hormones Circadian rhythm Median preoptic nucleus Neurons Glutamate Decarboxylase Suprachiasmatic nucleus General Neuroscience Neuropeptides Arcuate Nucleus of Hypothalamus Temperature Articles Preoptic Area Circadian Rhythm Rats Arginine Vasopressin Preoptic area Endocrinology Light effects on circadian rhythm alpha-MSH Hypothalamus Suprachiasmatic Nucleus Proto-Oncogene Proteins c-fos Antidiuretic Hormone Receptor Antagonists Photic Stimulation |
| Zdroj: | The Journal of Neuroscience. 35:15419-15429 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.1449-15.2015 |
| Popis: | In mammals, daily changes in body temperature (Tb) depend on the integrity of the suprachiasmatic nucleus (SCN). Fasting influences the Tb in the resting period and the presence of the SCN is essential for this process. However, the origin of this circadian/metabolic influence is unknown. We hypothesized that, not only the SCN but also the arcuate nucleus (ARC), are involved in the Tb setting through afferents to the thermoregulatory median preoptic nucleus (MnPO). Therefore, we investigated by neuronal tracing and microdialysis experiments the possible targeting of the MnPO by the SCN and the ARC in male Wistar rats. We observed that vasopressin release from the SCN decreases the temperature just before light onset, whereas α-melanocyte stimulating hormone release, especially at the end of the dark period, maintains high temperature. Both peptides have opposite effects on the brown adipose tissue activity through thermoregulatory nuclei such as the dorsomedial nucleus of the hypothalamus and the dorsal raphe nucleus. The present study indicates that the coordination between circadian and metabolic signaling within the hypothalamus is essential for an adequate temperature control.SIGNIFICANCE STATEMENTWhen circadian and metabolic systems are not well synchronized, individuals may develop metabolic diseases. The underlying mechanisms are unknown. Here, we demonstrate that the balance between the releases of neuropeptides derived from the biological clock and from a metabolic sensory organ as the arcuate nucleus, are essential for an adequate temperature control. These observations show that brain areas involved in circadian and metabolic functions of the body need to interact to produce a coherent arrangement of physiological processes associated with temperature control. |
| Databáze: | OpenAIRE |
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