Association between brain-derived neurotrophic factor and von Willebrand factor levels in patients with stable coronary artery disease
Autor: | Yi-fei Chen, Long Chen, Yi Zhu, Genshan Ma, Hong Jin, Xi-Qiong Han, Naifeng Liu, Bilei Wang |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Male
0301 basic medicine medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system Time Factors Endothelium Enzyme-Linked Immunosorbent Assay Von Willebrand factor 030204 cardiovascular system & hematology Coronary Angiography Coronary artery disease Brain-derived neurotrophic factor Angina Pectoris Angina 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine Diabetes mellitus medicine Humans Endothelial dysfunction Aged biology business.industry Area under the curve Middle Aged medicine.disease Prognosis 030104 developmental biology medicine.anatomical_structure Endocrinology ROC Curve lcsh:RC666-701 Area Under Curve Case-Control Studies biology.protein Female Endothelium Vascular Cardiology and Cardiovascular Medicine business Biomarkers Research Article |
Zdroj: | BMC Cardiovascular Disorders, Vol 18, Iss 1, Pp 1-8 (2018) BMC Cardiovascular Disorders |
ISSN: | 1471-2261 |
Popis: | Background Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in angiogenesis and maintenance of endothelial integrity. Whether circulating BDNF levels are associated with von Willebrand factor (vWF) levels, which are indicators of endothelial dysfunction is not known. This study investigated the association between plasma BNDF and vWF levels and whether these biomarkers could predict cardiovascular events at a 12-month follow-up in patients with stable coronary artery disease (CAD). Methods We recruited 234 patients with suspected angina pectoris. Subjects were divided into CAD (n = 143) and control (n = 91) groups based on coronary angiography. Plasma BDNF and vWF levels were measured using ELISA. Patients were followed-up for one year, and information on adverse cardiac events was collected. Results CAD patients exhibited significantly lower plasma BDNF and higher vWF levels than those of control patients. High vWF levels were associated with low BDNF levels even after adjustment for age, gender, low-density lipoprotein (LDL) levels, and the presence of diabetes mellitus. A receiver operating characteristic curve was used to determine whether low BDNF and high vWF levels could predict adverse cardiovascular events. The area under the curve for vWF and the inverse of BDNF were 0.774 and 0.804, respectively. Conclusions These findings suggest that endothelial dysfunction is an important determinant of the impaired circulating BDNF levels, and they further reflected cardiovascular prognosis in stable CAD patients. |
Databáze: | OpenAIRE |
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