Association between brain-derived neurotrophic factor and von Willebrand factor levels in patients with stable coronary artery disease

Autor: Yi-fei Chen, Long Chen, Yi Zhu, Genshan Ma, Hong Jin, Xi-Qiong Han, Naifeng Liu, Bilei Wang
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Time Factors
Endothelium
Enzyme-Linked Immunosorbent Assay
Von Willebrand factor
030204 cardiovascular system & hematology
Coronary Angiography
Coronary artery disease
Brain-derived neurotrophic factor
Angina Pectoris
Angina
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Risk Factors
Internal medicine
Diabetes mellitus
medicine
Humans
Endothelial dysfunction
Aged
biology
business.industry
Area under the curve
Middle Aged
medicine.disease
Prognosis
030104 developmental biology
medicine.anatomical_structure
Endocrinology
ROC Curve
lcsh:RC666-701
Area Under Curve
Case-Control Studies
biology.protein
Female
Endothelium
Vascular
Cardiology and Cardiovascular Medicine
business
Biomarkers
Research Article
Zdroj: BMC Cardiovascular Disorders, Vol 18, Iss 1, Pp 1-8 (2018)
BMC Cardiovascular Disorders
ISSN: 1471-2261
Popis: Background Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in angiogenesis and maintenance of endothelial integrity. Whether circulating BDNF levels are associated with von Willebrand factor (vWF) levels, which are indicators of endothelial dysfunction is not known. This study investigated the association between plasma BNDF and vWF levels and whether these biomarkers could predict cardiovascular events at a 12-month follow-up in patients with stable coronary artery disease (CAD). Methods We recruited 234 patients with suspected angina pectoris. Subjects were divided into CAD (n = 143) and control (n = 91) groups based on coronary angiography. Plasma BDNF and vWF levels were measured using ELISA. Patients were followed-up for one year, and information on adverse cardiac events was collected. Results CAD patients exhibited significantly lower plasma BDNF and higher vWF levels than those of control patients. High vWF levels were associated with low BDNF levels even after adjustment for age, gender, low-density lipoprotein (LDL) levels, and the presence of diabetes mellitus. A receiver operating characteristic curve was used to determine whether low BDNF and high vWF levels could predict adverse cardiovascular events. The area under the curve for vWF and the inverse of BDNF were 0.774 and 0.804, respectively. Conclusions These findings suggest that endothelial dysfunction is an important determinant of the impaired circulating BDNF levels, and they further reflected cardiovascular prognosis in stable CAD patients.
Databáze: OpenAIRE
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