Extracellular Transduction Events Under Pulsed Stimulation in Moth Olfactory Sensilla
| Autor: | Vlastimil Křivan, Jean-Pierre Rospars, Petr Lánský |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Periodicity
Time Factors Physiology Stimulation Moths Biology Stimulus (physiology) Receptors Odorant Models Biological Olfactory Receptor Neurons Antheraea polyphemus Behavioral Neuroscience Physiology (medical) Extracellular medicine Animals Pheromone binding Sex Attractants Communication business.industry Sense Organs biology.organism_classification Stimulation Chemical Sensory Systems medicine.anatomical_structure Sex pheromone Biophysics Insect Proteins Pheromone Neuron Carrier Proteins business Signal Transduction |
| Zdroj: | Chemical Senses. 28:509-522 |
| ISSN: | 1464-3553 |
| DOI: | 10.1093/chemse/28.6.509 |
| Popis: | In natural conditions, pheromones released continuously by female moths are broken in discontinuous clumps and filaments. These discontinuities are perceived by flying male moths as periodic variations in the concentration of the stimulus, which have been shown to be essential for location of females. We study analytically and numerically the evolution in time of the activated pheromone-receptor (signaling) complex in response to periodic pulses of pheromone. The 13-reaction model considered takes into account the transport of pheromone molecules by pheromone binding proteins (PBP), their enzymatic deactivation in the perireceptor space and their interaction with receptors at the dendritic membrane of neurons in Antheraea polyphemus sensitive to the main pheromone component. The time-averaged and periodic properties of the temporal evolution of the signaling complex are presented, in both transient and steady states. The same time-averaged response is shown to result from many different pulse trains and to depend hyperbolically on the time-averaged pheromone concentration in air. The dependency of the amplitude of the oscillations of the signaling complex on pulse characteristics, especially frequency, suggests that the model can account for the ability of the studied type of neuron to resolve repetitive pulses up to 2 Hz, as experimentally observed. Modifications of the model for resolving pulses up to 10 Hz, as found in other neuron types sensitive to the minor pheromone components, are discussed. |
| Databáze: | OpenAIRE |
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