Magnetic Nanostructure-Coated Thermoresponsive Hydrogel Nanoconstruct As a Smart Multimodal Theranostic Platform
| Autor: | Soo-Ryoon Ryoo, Vinayak P. Dravid, Vikas Nandwana, Tiffany S. Zheng, Marisa M. You |
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| Rok vydání: | 2019 |
| Předmět: |
Nanostructure
Materials science Contrast enhancement 0206 medical engineering Biomedical Engineering Nanotechnology 02 engineering and technology 021001 nanoscience & nanotechnology 020601 biomedical engineering Mr imaging Rf field Biomaterials Magnetic hyperthermia Free drug Nanocarriers 0210 nano-technology Human breast |
| Zdroj: | ACS Biomaterials Science & Engineering. 5:3049-3059 |
| ISSN: | 2373-9878 |
| DOI: | 10.1021/acsbiomaterials.9b00361 |
| Popis: | Here we report design of a smart nanoconstruct that can be used as a multimodal theranostic platform for imaging and therapy applications. Decorated with two sizes of magnetic nanostructures (MNS) on thermoresponsive nanosized hydrogel (NG), the NG-MNS nanoconstruct shows dual-mode contrast enhancement ability in MRI and thermo-chemo therapeutic ability under an RF field. Because of the unique design where all MNS are at the exterior of the nanoconstruct, no compromise in the physical properties of MNS and their effect on contrast enhancement and thermal activation has been observed. In a series of in vitro analyses in human breast adenocarcinoma (MDA-MB-231) cells, we validate that NG-MNS show dual-mode MR imaging capability with a higher signal/noise ratio than in clinically approved dual-mode contrast agents as well as enhanced therapeutic efficacy compared to previously reported hydrogel-based nanocarriers and free drug systems. |
| Databáze: | OpenAIRE |
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