Venoarterial PCO2-to-arteriovenous oxygen content difference ratio is a poor surrogate for anaerobic metabolism in hemodilution: an experimental study
| Autor: | Héctor Canales, Carlos Canullán, Arnaldo Dubin, Enrique Martins, Vanina Siham Kanoore Edul, Gastón Murias, Gonzalo Ferrara, Elisa Estenssoro, Mario Omar Pozo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Anemia
chemistry.chemical_element Hemorrhage Anaerobic metabolism Critical Care and Intensive Care Medicine Oxygen pCO2 03 medical and health sciences 0302 clinical medicine Medicine 030212 general & internal medicine Oxygen content Respiratory quotient Hemodilution business.industry Critically ill lcsh:Medical emergencies. Critical care. Intensive care. First aid 030208 emergency & critical care medicine lcsh:RC86-88.9 medicine.disease chemistry Carbon dioxide Anesthesia Ciencias Médicas Base excess business Anaerobic exercise |
| Zdroj: | Annals of Intensive Care, Vol 7, Iss 1, Pp 1-7 (2017) SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP |
| ISSN: | 2110-5820 |
| DOI: | 10.1186/s13613-017-0288-z |
| Popis: | Background: The identification of anaerobic metabolism in critically ill patients is a challenging task. Observational studies have suggested that the ratio of venoarterial PCO2 (Pv–aCO2) to arteriovenous oxygen content difference (Ca–vO2) might be a good surrogate for respiratory quotient (RQ). Yet Pv–aCO2/Ca–vO2 might be increased by other factors, regardless of anaerobic metabolism. At present, comparisons between Pv–aCO2/Ca–vO2 and RQ have not been performed. We sought to compare these variables during stepwise hemorrhage and hemodilution. Since anemia predictably produces augmented Pv–aCO2 and decreased Ca–vO2, our hypothesis was that Pv–aCO2/Ca–vO2 might be an inadequate surrogate for RQ. Methods: This is a subanalysis of a previously published study. In anesthetized and mechanically ventilated sheep (n = 16), we compared the effects of progressive hemodilution and hemorrhage by means of expired gases analysis. Results: There were comparable reductions in oxygen consumption and increases in RQ in the last step of hemodilution and hemorrhage. The increase in Pv–aCO2/Ca–vO2 was higher in hemodilution than in hemorrhage (1.9 ± 0.2 to 10.0 ± 0.9 vs. 1.7 ± 0.2 to 2.5 ± 0.1, P Facultad de Ciencias Médicas |
| Databáze: | OpenAIRE |
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