Bioactive Constituents of Chinese Natural Medicines. IV. Rhodiolae Radix. (2).: On the Histamine Release Inhibitors from the Underground Part of Rhodiola sacra (PRAIN ex HAMET) S. H. Fu (Crassulaceae): Chemical Structures of Rhodiocyanoside D and Sacranosides A and B
| ISSN: | 1347-5223 0009-2363 |
|---|---|
| DOI: | 10.1248/cpb.45.1498 |
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3cdac96da259b627bcf0599b4b26a5 https://doi.org/10.1248/cpb.45.1498 |
| Rights: | OPEN |
| Přírůstkové číslo: | edsair.doi.dedup.....6f3cdac96da259b627bcf0599b4b26a5 |
| Autor: | Johji Yamahara, Hiroshi Shimoda, Sugako Horikawa, Masayuki Yoshikawa, Hiromi Shimada, Hisashi Matsuda, Toshiyuki Murakami |
| Rok vydání: | 1997 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry Monoterpene Spectrometry Mass Fast Atom Bombardment Pharmacognosy Disaccharides Lotaustralin chemistry.chemical_compound Glucosides Nitriles Drug Discovery Carbohydrate Conformation Animals Medicine Chinese Traditional Peritoneal Cavity chemistry.chemical_classification Plants Medicinal biology Traditional medicine Terpenes Chemistry Glycoside Biological activity General Chemistry General Medicine biology.organism_classification Terpenoid Rats Crassulaceae Histamine H1 Antagonists Histamine |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 45:1498-1503 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.45.1498 |
| Popis: | The methanolic extract of the underground part of Rhodiola sacra (PRAIN ex HAMET) S. H. Fu was found to show inhibitory activity on the histamine release from rat peritoneal exudate cells induced by an antigen-antibody reaction. From the methanolic extract with the inhibitory activity on histamine release, a new cyanoglycoside called rhodiocyanoside D and two new monoterpene glycosides called sacranosides A and B were isolated, together with eight known compounds, rhodiocyanoside A, heterodendrin, lotaustralin, rhodioloside, 2-phenylethyl alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside, 2-methyl-3-buten-2-yl beta-D-glucopyranoside, kenposide A, and rhodiooctanoside. The structures of new compounds were determined on the basis of chemical and physicochemical evidence, which included the synthesis of sacranoside A from (-)-myrtenol. All major chemical constituents from R. sacra inhibited the histamine release and, among them, lotaustralin and rhodiooctanoside were found to show potent inhibitory activity. |
| Databáze: | OpenAIRE |
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