Differential effects of midazolam and zolpidem on sleep-wake states and epileptic activity in WAG/Rij rats
| Autor: | H. Depoortere, E.L.J.M. van Luijtelaar, W.H.I.M. Drinkenburg, A.M.L. Coenen, D. Françon |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Zolpidem Pyridines medicine.drug_class Midazolam medicine.medical_treatment Clinical Biochemistry Sleep REM Electroencephalography Pharmacology Toxicology Biochemistry Hypnotic Behavioral Neuroscience Epilepsy medicine Animals Hypnotics and Sedatives Wakefulness Biological Psychiatry Benzodiazepine medicine.diagnostic_test Rats Inbred Strains medicine.disease Rats Anticonvulsant Epilepsy Absence Anesthesia Anticonvulsants Sleep Psychology medicine.drug |
| Zdroj: | Pharmacology, Biochemistry and Behavior, 51, 571-576. Pergamon-elsevier science ltd Pharmacology, Biochemistry and Behavior, 51, 4, pp. 571-576 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(95)00091-a |
| Popis: | Contains fulltext : 29204.pdf (Publisher’s version ) (Open Access) Hypnotic drugs are known to possess antiepileptic activity. Therefore, the effects of the benzodiazepine hypnotic midazolam (10 mg/kg) and the novel imidazopyridine hypnotic zolpidem (10 mg/kg) on sleep-wake states and on the number of spike-wave discharges were evaluated in WAG/Rij rats. Rats of this strain are considered to be a model for generalized absence epilepsy. Animals were implanted with chronic monopolar EEG electrodes and, after recovery from surgery, the EEG was recorded for 6 h during the dark period on 3 consecutive days. Sleep recordings were analyzed using Hjorth's parameters and number and duration of spike-wave discharges were visually determined. It was found that both drugs facilitated nonREM sleep at the cost of wakefulness. Both hypnotics also reduced the number and duration of spike-wave discharges. The initial decrease after midazolam, however, was followed by a rebound reflecting a poorer quality of vigilance expressed as an increase in spike-wave discharges. The strong antiabsence activity of zolpidem mimics that of midazolam and is well correlated with their equipotent hypnotic action and anticonvulsant effect in the isoniazid test. |
| Databáze: | OpenAIRE |
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