Sites of vasodilation by inhaled nitric oxide vs. sodium nitroprusside in endothelin-constricted isolated rat lungs
| Autor: | M. O. Daugherty, George F. Rich, C. M. Roos, Deborah U. Frank, D. R. Uncles |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Nitroprusside Pulmonary Circulation medicine.medical_specialty Physiology Hypertension Pulmonary Blood Pressure Vasodilation In Vitro Techniques Nitric Oxide Models Biological Nitric oxide Rats Sprague-Dawley chemistry.chemical_compound Physiology (medical) Internal medicine Administration Inhalation medicine Animals Lung Lung Compliance business.industry Endothelins Rats Compliance (physiology) Endocrinology chemistry Anesthesia Sodium nitroprusside Endothelin receptor business Pulmonary vasodilators medicine.drug |
| Zdroj: | Journal of Applied Physiology. 77:51-57 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1994.77.1.51 |
| Popis: | We localized the sites of vasodilation of inhaled nitric oxide (NO), a selective pulmonary vasodilator, and sodium nitroprusside (SNP) in isolated rat lungs. The sites were determined by analyzing the arterial, venous, and double-occlusion data with a two-resistor (small arteries and veins) three-capacitor (large arteries, large veins, and capillaries) model of the pulmonary vascular bed. Inhaled NO (170 and 670 ppm) and SNP (22.5 and 45.0 micrograms) decreased the small-artery resistance by 7.4 +/- 1.6, 17.2 +/- 2.2, 14.2 +/- 2.8, and 21.4 +/- 3.4% and the small-vein resistance by 13.5 +/- 3.2, 20.3 +/- 3.4 (SNP of 22.5 micrograms not significant), and 9.3 +/- 3.3%, respectively, in blood-perfused lungs (n = 12). Similar results were observed in Krebs-perfused lungs (n = 12). Capillary compliance was unaffected by inhaled NO and SNP. SNP increased the large-artery capacitance by 40.0 +/- 8.6 and 69.3 +/- 9.7%, whereas inhaled NO had no effect. SNP increased the large-vein capacitance by 31.0 +/- 8.7 and 48.0 +/- 10.7%, whereas inhaled NO had no effect in blood-perfused lungs. However, in Krebs-perfused lungs inhaled NO and SNP (45.0 micrograms only) increased the large-vein capacitance by 43.3 +/- 11.9, 41.4 +/- 14.2, and 44.2 +/- 11.0%. In conclusion, in blood-perfused isolated rat lungs inhaled NO and SNP dilate small-resistance arteries and veins, whereas SNP but not inhaled NO dilates larger capacitance arteries and veins. Furthermore, blood appears to prevent the downstream vasodilation by inhaled NO on larger capacitance pulmonary veins. |
| Databáze: | OpenAIRE |
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