Effect of Zinc Sulfate on Sensorineural Olfactory Disorder
| Autor: | Junko Mori, Kohji Matsumoto, Midori Sugiura, Yoshiaki Nakai, Fumiyuki Okuda, Tsunemasa Aiba, Kenta Tomiyama |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Olfactory Receptor Cell chemistry.chemical_element Olfaction Zinc Neurological disorder Receptors Odorant Olfaction Disorders Internal medicine Precursor cell Craniocerebral Trauma Humans Medicine Receptor Chemotherapy business.industry General Medicine medicine.disease Zinc Sulfate Treatment Outcome Endocrinology medicine.anatomical_structure Otorhinolaryngology chemistry Virus Diseases business Olfactory epithelium |
| Zdroj: | Acta Oto-Laryngologica. 118:202-204 |
| ISSN: | 1651-2251 0001-6489 |
| DOI: | 10.1080/00016489850182936 |
| Popis: | We administered zinc sulfate to patients with sensorineural (post-viral, post-traumatic, or unknown aetiology) olfactory disorder and examined its effects. The patients were divided into three groups by method of treatment: zinc sulfate only, combination of zinc sulfate and the usual therapy, or the usual therapy. For disorders of post-viral and unknown aetiologies, there were no significant differences in improvement among the three groups. However, for post-traumatic olfactory disorder, the zinc sulfate groups had significantly higher improvement rates than did the group that received the usual therapy. The difference between post-traumatic and post-viral olfactory disorders in the effect of zinc sulfate therapy appeared to depend on the pathology of the associated lesions. In cases of post-traumatic olfactory disorder, regenerative capacity is retained in the olfactory epithelium because the blast cells of olfactory receptor cells remain intact. However, for post-viral olfactory disorder, the lack of olfactory receptor cells and blast cells due to viral infection results in loss of regenerative capacity. We also determined pre-treatment serum zinc concentrations in those patients who planned to be treated with zinc sulfate. Pre-treatment serum zinc concentration was not significantly related to improvement rates. |
| Databáze: | OpenAIRE |
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