Pharmaceutical quality of antimalarial drugs: quinine sulfate and Artemether/Lumefantrine tablets sold on Bukavu Market
| Autor: | Aline Zawadi Mahano, Félicien Mushagalusa Kasali, Benjamin Bavurhe Zirirane, Lucien Murhula Namegabe, Ntokamunda Justin Kadima, Aladin Ombeni Mahano, Nelson Hendwa Cubaka, Pacifique Murhula Hamuli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Artemether/lumefantrine
Population RM1-950 Lumefantrine chemistry.chemical_compound Pharmacy and materia medica medicine Artemether education Active ingredient education.field_of_study Quinine Traditional medicine business.industry Quality control RS1-441 chemistry Congo Quinine Sulfate Therapeutics. Pharmacology business medicine.drug |
| Zdroj: | Future Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-8 (2021) |
| ISSN: | 2314-7253 |
| Popis: | Background Generic antimalarial drugs sold in sub-Saharan Africa require tighter control as counterfeiting has grown more and more out of control. The study aimed to analyze the pharmaceutical quality of quinine sulfate (QS) and Artemether/Lumefantrine(AL) tablets marketed in Bukavu city compared to the current trends in other African cities. Results The samples were purchased in community pharmacies or from ambulatory street vendors and analyzed using a set of thirteen simple tests, including visual inspection, UV spectrometry, TLC, and conventional quality control procedures. More than 93% of AL samples had an acceptable global quality score of > 90%. Around 16.6% of QS batches did not satisfy the requirements about hardness, friability, and mass uniformity. Only 33.3% met the disintegration quality; 33.3% did not contain quinine; 8.33% had an active ingredient other than quinine. Conclusion The findings strongly alert the circulation of fake antimalarial medicines observed in many countries. Simple TLC procedures may help to detect any low-quality generics to avoid microbial resistance and guarantee the health of the population. Pharmacists and regulatory authorities are alerted to the circulation of low-quality generic quinine preparations in the country. |
| Databáze: | OpenAIRE |
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