| Popis: |
Complete molecular mechanisms that underlie inflammatory responses in chronic obstructive pulmonary disease (COPD) are still unknown but seem to be associated with chronic exposure to noxious particles or gases, particularly cigarette smoke, and genetic susceptibility. The aim of this study was to explore gene expressions of HSP70 as well as TLR2 and TLR4 (the main receptors for extracellular Hsp70), and association of their polymorphisms with risk of COPD. 137 patients with stable COPD and 95 controls were included in the study. Real-time polymerase chain reaction was used for the determination of HSP70, TLR2 and TLR4 mRNA expressions as well as for genotyping for single nucleotide polymorphisms (SNPs) of HSP70 (rs1008438, rs6457452), TLR2 (rs1898830, rs3804099, rs13150331) and TLR4 (rs2737190, rs10759932, rs7846989) genes. Levels of HSP70 (P |
