SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release
| Autor: | Jonathan Abraham, Michael Filbin, F. Ho, Judy Lieberman, Erin Janssen, Shahin Ranjbar, Setu M. Vora, Upasana Das Adhikari, Caroline Beakes, Douglas S. Kwon, N. Russell, Hao Wu, Steven Bell, Chris Sander, M. Lewandrowski, Angela Crespo, Sarah Clark, Lauren A. Henderson, Caroline Junqueira, Sagi Ravid, Justin D. Margolin, Gautam Mehta, Kyle R. Kays, Blair Parry, Marcia B. Goldberg, Anne E. Goldfeld, J. Ingber, Lee Gehrke, Valerie Leger, L. B. de Lacerda |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
AIM2 Inflammation CD16 Systemic inflammation Article Immune system NLRP3 inflammasome medicine SARS-CoV-2 business.industry pyroptosis Monocyte Pyroptosis COVID-19 Inflammasome antibody-dependent phagocytosis medicine.anatomical_structure Cytokine monocyte Immunology medicine.symptom business medicine.drug |
| Zdroj: | Research Square article-version (status) pre article-version (number) 1 |
| Popis: | SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and death in a minority of patients. Although severe COVID-19 disease is linked to exuberant inflammation, how SARS-CoV-2 triggers inflammation is not understood. Monocytes and macrophages are sentinel immune cells in the blood and tissue, respectively, that sense invasive infection to form inflammasomes that activate caspase-1 and gasdermin D (GSDMD) pores, leading to inflammatory death (pyroptosis) and processing and release of IL-1 family cytokines, potent inflammatory mediators. Here we show that expression quantitative trait loci (eQTLs) linked to higher GSDMD expression increase the risk of severe COVID-19 disease (odds ratio, 1.3, p One sentence summary: Antibody-mediated SARS-CoV-2 infection of monocytes activates inflammation and cytokine release. |
| Databáze: | OpenAIRE |
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