Cyclic Oligosaccharide-Based Chiral Stationary Phases Applicable to Drug Purity Control; A Review
| Autor: | Kveta Kalikova, Tereza Šlechtová, Eva Tesarova |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Capillary electrochromatography Chromatography Gas Chromatography Cyclodextrin 010401 analytical chemistry Organic Chemistry Enantioselective synthesis Oligosaccharides Cyclic oligosaccharide Oligosaccharide 010402 general chemistry 01 natural sciences Biochemistry High-performance liquid chromatography 0104 chemical sciences Pharmaceutical Preparations chemistry Drug Discovery Supercritical fluid chromatography Molecular Medicine Gas chromatography Chromatography High Pressure Liquid |
| Zdroj: | Current Medicinal Chemistry. 24:829-848 |
| ISSN: | 0929-8673 |
| Popis: | Oligosaccharide-based chiral stationary phases are frequently used for enantioselective separations by different chromatographic techniques, namely gas chromatography, high performance liquid chromatography, supercritical fluid chromatography or capillary electrochromatography. Their multimodal application potential (they are compatible with both polar and/or non-polar mobile phases) makes them suitable chiral selector candidates for separation of a wide variety of structurally diverse compounds. In this paper, separation systems utilizing cyclodextrin- or cyclofructan-based chiral stationary phases in analyses of pharmacologically active compounds are summarized. The review covers the period from 2000 to 2015. This review article can be helpful to analysts searching for an appropriate method for the separation/determination of pharmaceuticals of their interest. |
| Databáze: | OpenAIRE |
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