HLA DR15 (DR2) and DQB1*0602 typing studies in 188 narcoleptic patients with cataplexy
| Autor: | Emmanuel Mignot, J. Meehan, Ann E. Rogers, F. C. Grumet, Christian Guilleminault |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Multiple Sleep Latency Test Pediatrics medicine.medical_specialty Cataplexy Polysomnography Black People Excessive daytime sleepiness Neurological disorder Human leukocyte antigen White People Sex Factors Asian People HLA-DQ Antigens medicine HLA-DQ beta-Chains Humans HLA-DR Serological Subtypes Sleep disorder medicine.diagnostic_test Histocompatibility Testing HLA-DR Antigens medicine.disease Anesthesia Female Neurology (clinical) medicine.symptom Psychology Biomarkers Narcolepsy |
| Zdroj: | Neurology. 48:1550-1556 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.48.6.1550 |
| Popis: | Narcolepsy is considered a homogeneous clinical entity when excessive daytime sleepiness and cataplexy are present. Cataplexy is a polymorphic symptom that can be very mild and is thus subjectively defined. The Multiple Sleep Latency Test (MSLT) is widely used as a diagnostic test for narcolepsy. A short mean sleep latency and multiple sleep onset REM periods (SOREMPs) are typically observed in narcoleptic patients. The discovery of a tight association of narcolepsy with HLA class II antigens offers a unique opportunity to explore the respective value of the MSLT or of the presence of clear-cut cataplexy in defining an etiologically homogeneous group of narcoleptic patients. In this study, we carried out HLA typing for DR15(DR2) and DQB1*0602 in 188 narcoleptic patients with cataplexy in three ethnic groups (24 Asians, 61 Blacks, and 103 Caucasians). These results confirm the importance of DQB1*0602 typing rather than DR15 (DR2) typing in Black narcoleptic patients and demonstrate that the presence of clear-cut cataplexy is a better predictor for DQB1*0602 positivity than the presence of abnormal MSLT results. |
| Databáze: | OpenAIRE |
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