Targeting of temozolomide using magnetic nanobeads: an in vitro study
| Autor: | Ali Demir Sezer, Cem L. Altan, Seyda Malta, Elçin Yenigül, Berna Gurten |
|---|---|
| Přispěvatelé: | Gurten, Berna, Yenigul, Elcin, Sezer, Ali Demir, Altan, Cem, Malta, Seyda |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Drug
SURFACE media_common.quotation_subject PACLITAXEL 030226 pharmacology & pharmacy 01 natural sciences Chitosan Magnetite 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacy and materia medica medicine Temozolomide NANOPARTICLES In vitro study Cyclodextrin DRUG-DELIVERY media_common chemistry.chemical_classification RELEASE Targeting MICELLES STABILITY Delivery vehicle Chemistry equipment and supplies CYCLODEXTRIN 0104 chemical sciences RS1-441 010404 medicinal & biomolecular chemistry REDUCTION Anticancer Targeted drug delivery Drug delivery Biophysics medicine.drug |
| Zdroj: | Brazilian Journal of Pharmaceutical Sciences, Vol 56 (2020) Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18579 Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18579 Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo (USP) instacron:USP Brazilian Journal of Pharmaceutical Sciences, Volume: 56, Article number: e18579, Published: 18 SEP 2020 |
| ISSN: | 2175-9790 1984-8250 |
| Popis: | Temozolomide, a chemotherapeutic drug that is often administered for the treatment of brain cancer has severe side effects and a poor aqueous solubility. In order to decrease the detrimental effect of the drug over healthy cells, a novel drug delivery vehicle was developed where the therapeutic drug was encapsulated within the hydrophobic cavities of beta-CD modified magnetite nanoparticles, which are embedded in chitosan nanobeads prepared by salt addition. In-vitro studies have shown that the magnetic properties of the novel delivery vehicle are adequate for targeted drug delivery applications under an external magnetic field. Additionally, an increase in the amount of chitosan was shown to exhibit a strong shielding effect over the magnetic properties of the delivery vehicle, which lead to deterioration of the amount of captured drug at the targeted area, suggesting a delicate balance between the amounts of constituents composing the drug delivery vehicle. |
| Databáze: | OpenAIRE |
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