Serum glucose, triglycerides, and cholesterol in relation to prostate cancer death in the Swedish AMORIS study
| Autor: | Göran Walldius, Henrik Møller, Pär Stattin, Mieke Van Hemelrijck, Niklas Hammar, Lars Holmberg, Rhonda Arthur, Hans Garmo, Mats Lambe, Håkan Malmström, David Robinson, Ingmar Jungner, Christel Häggström |
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| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male Oncology Cancer Research medicine.medical_specialty Cohort Studies 03 medical and health sciences chemistry.chemical_compound Prostate cancer 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Triglycerides Aged Proportional Hazards Models Sweden Cholesterol business.industry Proportional hazards model Hazard ratio Prostatic Neoplasms Middle Aged medicine.disease Obesity Quartile chemistry 030220 oncology & carcinogenesis Cohort business Dyslipidemia |
| Zdroj: | Arthur, R, Møller, H, Garmo, H, Häggström, C, Holmberg, L, Stattin, P, Malmström, H, Lambe, M, Hammar, N, Walldius, G, Robinson, D, Jungner, I & Van Hemelrijck, M 2018, ' Serum glucose, triglycerides and cholesterol in relation to prostate cancer death in the Swedish AMORIS study ', Cancer Causes and Control . https://doi.org/10.1007/s10552-018-1093-1 |
| ISSN: | 1573-7225 0957-5243 |
| Popis: | PurposeLifestyle-related conditions such as obesity are associated with prostate cancer progression, but the associations with hyperglycemia and dyslipidemia are unclear. This study, therefore, aims to examine the association of glucose, triglycerides, and total cholesterol with prostate cancer death.MethodsFrom the Swedish AMORIS cohort, we selected 14,150 men diagnosed with prostate cancer between 1996 and 2011 who had prediagnostic measurements of serum glucose, triglycerides, and total cholesterol. Multivariable Cox proportional hazards regression models were used to determine the hazard ratios for death in relation to the aforementioned metabolic markers.ResultsUsing clinical cut-off points, a non-significant positive association was observed between glucose and prostate cancer death. When compared to those with glucose in the lowest quartile, those in the highest quartile had greater risk of prostate cancer death (HR 1.19; 95% CI 1.02–1.39). However, neither total cholesterol nor triglycerides were associated with prostate cancer death. Glucose and triglycerides were positively associated with overall, cardiovascular, and other deaths. Hypercholesterolemia was only associated with risk of CVD death.ConclusionOur results suggest that glucose levels may influence prostate cancer survival, but further studies using repeated measurements are needed to further elucidate how glucose levels may influence prostate cancer progression. |
| Databáze: | OpenAIRE |
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