Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-κB mediated hyper inflammation
| Autor: | Qinjie Ling, Jun Li, Chengwei Song, Chenghui Zhu, Shuimei Zhang, Peter R. Hoffmann, Tianfeng Chen, Yibo Zhang, Zhi Huang, Wenjie Zheng |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Antioxidant Selenium nanoparticles (SeNPs) Colon medicine.medical_treatment Anti-Inflammatory Agents Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Bioengineering Inflammation 02 engineering and technology Biology Pharmacology Applied Microbiology and Biotechnology Mice Selenium Ulva 03 medical and health sciences chemistry.chemical_compound Ulva lactuca polysaccharide (ULP) Polysaccharides medicine Animals Colitis Acute colitis Selenium (Se) CD68 business.industry Research NF-kappa B NF-κB Nuclear factor κ-B (NF-κB) 021001 nanoscience & nanotechnology medicine.disease NFKB1 Molecular medicine Biotechnology Mice Inbred C57BL 030104 developmental biology chemistry Nanoparticles Inflammatory bowel diseases (IBD) Molecular Medicine medicine.symptom 0210 nano-technology business |
| Zdroj: | Journal of Nanobiotechnology |
| ISSN: | 1477-3155 |
| DOI: | 10.1186/s12951-017-0252-y |
| Popis: | Background Selenium (Se) is an essential micronutrient trace element and an established nutritional antioxidant. Low Se status exacerbates inflammatory bowel diseases progression, which involves hyper inflammation in the digestive tract. Se nanoparticles (SeNPs) exhibit anti-inflammatory activity accompanied by low toxicity, especially when decorated with natural biological compounds. Herein, we explored the beneficial effects of SeNPs decorated with Ulva lactuca polysaccharide (ULP) in mice subjected to the acute colitis model. Results We constructed SeNPs coated with ULP (ULP-SeNPs) in average diameter ~130 nm and demonstrated their stability and homogeneity. Supplementation with ULP-SeNPs (0.8 ppm Se) resulted in a significant protective effect on DSS-induced acute colitis in mice including mitigation of body weight loss, and colonic inflammatory damage. ULP-SeNPs ameliorated macrophage infiltration as evidenced by decreased CD68 levels in colon tissue sections. The anti-inflammatory effects of ULP-SeNPs were found to involve modulation of cytokines including IL-6 and TNF-α. Mechanistically, ULP-SeNPs inhibited the activation of macrophages by suppressing the nuclear translocation of NF-κB, which drives the transcription of these pro-inflammatory cytokines. Conclusions ULP-SeNPs supplementation may offer therapeutic potential for reducing the symptoms of acute colitis through its anti-inflammatory actions. Electronic supplementary material The online version of this article (doi:10.1186/s12951-017-0252-y) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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