Fractional anisotropy of white matter, disability and blood iron parameters in multiple sclerosis
| Autor: | Penelope Engel-Hills, Christine Lochner, Martin Kidd, Jean-Paul Fouche, Susan J. van Rensburg, Coenraad J. Hattingh, Maritha J. Kotze, Estelle Herbert |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Multiple Sclerosis Iron Biochemistry Gastroenterology White matter 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Internal medicine Fractional anisotropy medicine Humans Expanded Disability Status Scale biology medicine.diagnostic_test Transferrin saturation business.industry Multiple sclerosis Confounding Middle Aged medicine.disease White Matter Ferritin Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging 030104 developmental biology medicine.anatomical_structure biology.protein Serum iron Anisotropy Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Metabolic Brain Disease. 33:545-557 |
| ISSN: | 1573-7365 0885-7490 |
| Popis: | Multiple sclerosis (MS) is a disorder related to myelin damage, which can be investigated by neuroimaging techniques such as fractional anisotropy (FA), a measure of microstructural white matter properties. The objectives of this study were to investigate (1) the relationship between FA and disability using an extremes of outcome approach, and (2) whether blood iron parameters were associated with FA and/or disability. Patients diagnosed with MS (n = 107; 14 males and 93 females) had iron parameter tests and disability determinations using the Expanded Disability Status Scale (EDSS). FA was recorded in 48 white matter tracts in 11 of the female patients with MS and 12 female controls. Results: In patients with high disability scores the mean FA was significantly lower (0.34 ± 0.067) than in the control group (0.45 ± 0.036; p = 0.04), while patients with low disability had mean FA values (0.44 ± 0.014) similar to controls (p = 0.5). Positive associations were found between FA and the iron parameters serum iron, ferritin and percentage transferrin saturation (%Tfsat) in all the white matter tracts. For % Tfsat, the associations were highly significant in 14 tracts (p |
| Databáze: | OpenAIRE |
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