Circulating Fatty Acid Synthase in pregnant women: Relationship to blood pressure, maternal metabolism and newborn parameters
| Autor: | Francis de Zegher, Gemma Carreras-Badosa, Ericka Mendoza, Teresa Puig, Anna Prats-Puig, Monserrat Bruel, Abel López-Bermejo, Lourdes Ibáñez, Montserrat Vázquez-Ruíz, Judit Bassols |
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| Přispěvatelé: | Universitat de Barcelona |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Síndrome metabòlica medicine.medical_treatment Placenta Embaràs Àcids grassos Blood Pressure Biology Article Gene Expression Regulation Enzymologic 03 medical and health sciences Embarassades 0302 clinical medicine Insulin resistance Pregnancy Internal medicine medicine Humans Insulin Fatty acids Fetus Multidisciplinary Pregnant women Infant Newborn medicine.disease Lipid Metabolism Complicacions en l'embaràs Metabolic syndrome Fatty acid synthase 030104 developmental biology Blood pressure Endocrinology medicine.anatomical_structure Glucose 030220 oncology & carcinogenesis Complications of pregnancy Hypertension biology.protein Gestation Female Hipertensió Fatty Acid Synthases Insulin Resistance |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Scientific Reports, núm. 6, art. 24167 Articles publicats (D-CM) DUGiDocs – Universitat de Girona instname Recercat. Dipósit de la Recerca de Catalunya Scientific Reports |
| Popis: | The enzyme FASN (fatty acid synthase) is potentially related with hypertension and metabolic dysfunction. FASN is highly expressed in the human placenta. We aimed to investigate the relationship circulating FASN has with blood pressure, maternal metabolism and newborn parameters in healthy pregnant women. Circulating FASN was assessed in 115 asymptomatic pregnant women in the second trimester of gestation along with C-peptide, fasting glucose and insulin, post-load glucose lipids, HMW-adiponectin and blood pressure (the latter was assessed in each trimester of gestation). At birth, newborns and placentas were weighed. FASN expression was also able to be assessed in 80 placentas. Higher circulating FASN was associated with lower systolic blood pressure (SBP), with a more favourable metabolic phenotype (lower fasting glucose and insulin, post load glucose, HbAc1, HOMA-IR and C-peptide), and with lower placental and birth weight (all p FASN expression related positively to circulating FASN (p |
| Databáze: | OpenAIRE |
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