Atrial Natriuretic Peptide in the Central Nervous System
| Autor: | C.S. Cockram, R. Teoh, T.G. Yandle, J.D. Young, M.G. Nicholls, Vincent T.F. Yeung, C.K. Lai |
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| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Cell type Endocrinology Diabetes and Metabolism Central nervous system Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Atrial natriuretic peptide Internal medicine medicine Animals Humans Binding site Cyclic GMP Cyclic guanosine monophosphate Brain Chemistry Neurons Endocrine and Autonomic Systems Chemistry NPR1 NPR2 medicine.anatomical_structure Astrocytes cardiovascular system Atrial Natriuretic Factor hormones hormone substitutes and hormone antagonists Astrocyte |
| Zdroj: | Neuroendocrinology. 53:18-24 |
| ISSN: | 1423-0194 0028-3835 |
| DOI: | 10.1159/000125790 |
| Popis: | Atrial natriuretic peptide (ANP), first isolated from rat atrial cardiocytes, is a potent natriuretic, diuretic and vasorelaxant hormone when given intravenously. In keeping with increasing evidence that many bioactive peptides that were first discovered in peripheral organs, are often present in the central nervous system, ANP and its binding sites have been localized on neurons in different regions of the brain. Further, ANP binding sites have been found on primary astrocyte and glial cell lines and ligand binding results in cyclic GMP production. In this review, we shall discuss the possible role of ANP as a neuromodulator and its effects on astrocytes, the most numerous cell type in mammalian brain. |
| Databáze: | OpenAIRE |
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