Chromosomes and stress
| Autor: | Dennis D. Kelly, Harlow K. Fischman |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Hypothalamo-Hypophyseal System Time Factors Mitomycin Pituitary-Adrenal System Sister chromatid exchange Mutagen Bone Marrow Cells medicine.disease_cause Chromosome aberration Rats Sprague-Dawley Internal medicine Conditioning Psychological medicine Psychogenic disease Endocrine system Sister chromatids Animals Chronic stress Hypophysectomy Nucleic Acid Synthesis Inhibitors Chromosome Aberrations Electroshock Chemistry General Neuroscience General Medicine Rats Endocrinology Chronic Disease Sister Chromatid Exchange Stress Psychological Hormone Mutagens |
| Zdroj: | The International journal of neuroscience. 99(1-4) |
| ISSN: | 0020-7454 |
| Popis: | The present investigation examines genotoxic effects of: prolonged periods of stress; the role of the endocrine system; and the relationship between psychogenic stress and chemical mutagens. Increased levels of both Sister Chromatid Exchanges (SCEs) and Chromosome Aberrations (CAs) were observed in male rats subjected to white noise of either 72 or 240 hrs duration, demonstrating that damage occurs during chronic stress. Rats subjected to foot-shock after having been either hypophysectomized or sham-operated, showed elevation of both SCEs and CAs, indicating that hormones in the hypothalamic-pituitary-adrenal axis do not play a role in genotoxic damage. Rats subjected to foot-shock, and/or the mutagen Mitomycin-C(MMC) showed elevated SCEs, both separately and together. The combined effect was the sum of the individual effects, demonstrating that synergism was not involved. This investigation establishes that psychogenic stress plays a role in genotoxic damage. |
| Databáze: | OpenAIRE |
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