Gestational age and cancer risk up to young adulthood in Swedish population born 1974 to 2013: A population-based cohort study
| Autor: | Elisabete Weiderpass, Nora Döring, Eva Steliarova-Foucher, Monica Sm Persson, Weiyao Yin, Kari R. Risnes, Sven Sandin |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent Birth weight Gestational Age Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors 030225 pediatrics Neoplasms medicine Humans Young adult Child Birth Year Sweden Obstetrics business.industry Hazard ratio Infant Newborn Gestational age Cancer Infant medicine.disease 3. Good health Oncology 030220 oncology & carcinogenesis Child Preschool Small for gestational age Premature Birth Female Age of onset business |
| Zdroj: | International journal of cancerREFERENCES. 150(8) |
| ISSN: | 1097-0215 |
| Popis: | We examined the association between gestational age and risk of any primary cancer and observed whether the risk patterns differed by sex, birth weight for gestational age categories, cancer site, and age of onset. All people live-born in Sweden 1974-2013 were prospectively followed up from birth until 2016 using national registers. Gestational age was extracted from the Medical Birth Register and primary malignant cancer diagnoses were from the Swedish cancer register. The adjusted hazard ratios (aHR) for any primary cancer according to weekly gestational age and gestational age categories were determined using cox proportional hazards models adjusted for birth year and parental age. The study included 3,137,691 people; 180,363 (5.8%) born preterm and 254,790 (8.1%) born post-term. They were followed up for 71,691,112 person-years, to a maximum of 43 years, and recorded 22,604 new cancers. Although aHRs for the pre-defined GA categories were only increased for moderate to late preterm delivery (aHR 1.07, 95%CI 1.01 to 1.14), gestational week-specific aHRs were increased for gestational weeks 30-35, with greatest aHR observed for 31 weeks (aHR 1.18, 95%CI 1.05 to 1.32). Increased cancer risk related to shorter gestational ages were observed particularly for women, those born small for gestational age, childhood cancers, and for cancers originating at certain sites (e.g., testicular and liver cancer). We provide the first evidence that those born between 30-35 weeks gestation may have increased risk of any primary malignant cancer up to young adulthood. Additionally, increasing gestational ages may reduce the risk of testicular and liver cancer. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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