Gilteritinib induces differentiation in relapsed and refractory FLT3-mutated acute myeloid leukemia

Autor:	Alexander E. Perl, Martin Carroll, Bryan Rea, Jonathan Canaani, Christopher D. Watt, Jennifer J.D. Morrissette, Julianne Qualtieri, Rachel L. Sargent, Christine M. McMahon
Rok vydání:	2019
Předmět:	Myeloid Cellular differentiation Gilteritinib Drug resistance medicine.disease_cause Refractory Recurrence hemic and lymphatic diseases medicine Humans Granulocyte Precursor Cells Mutation Aniline Compounds business.industry Myeloid leukemia Cell Differentiation Hematology medicine.disease Stimulus Report Leukemia Myeloid Acute Leukemia medicine.anatomical_structure fms-Like Tyrosine Kinase 3 Pyrazines Commentary Cancer research business
Zdroj:	Blood Advances. 3:1581-1585
ISSN:	2473-9537 2473-9529
DOI:	10.1182/bloodadvances.2018029496
Popis:	Key Points Gilteritinib induces 2 distinct marrow responses in FLT3-mutated AML: responses with and without differentiation. Ongoing clonal hematopoiesis is ubiquitous during gilteritinib therapy and may promote genetic evolution and drug resistance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f288f3d53d15c6db1c6b7ca9f47aa32 https://doi.org/10.1182/bloodadvances.2018029496 Zobrazit plný text záznamu