Response to Comment on 'Is There a Correlation Between Androgens and Sexual Desire in Women?'

Autor: Anette Tønnes Pedersen, Arieh Cohen, Nanna Cassandra Læssøe, Marika Lundquist, DMSc David M. Hougaard Md, Ellid Kristensen, Annamaria Giraldi, Sarah Wåhlin-Jacobsen
Rok vydání: 2015
Předmět:
Zdroj: The Journal of Sexual Medicine. 12:1851-1852
ISSN: 1743-6109
1743-6095
DOI: 10.1111/jsm.12945
Popis: The present study has a consistent hypothesis that androgens are involved in female sexual function, as one of the bio-psycho-social factors affecting women’s sexuality. The inconsistency in previous findings may be explained by insensitive steroid assays and/or intracrinology. It is claimed that our conclusion “presupposes an established correlation between androgens and sexual desire.” No assumption was made. The correlation is clearly demonstrated and discussed in our paper. The fact that both our and a previous study [3] do not find any statistically significant correlations between androsterone glucuronide (ADT-G) and female sexual function does not negate the relevance of intracellular androgen turnover in women. The choice of ADT-G as a biomarker of androgenic activity was based on previous findings, where ADT-G is proposed to represent 93% of the degradation products from the intracellular androgen turnover [4]. However, ADT-G is primarily indicative of adrenal preandrogen secretion [5], and a more complex mechanism might be involved. Our endpoints were based on the existing knowledge and research on the subject at the time being.
Databáze: OpenAIRE
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