The prognostic significance of bone marrow metastases: Evaluation of 58 cases
| Autor: | Ahmet Dirican, Aylin Orgen Calli, Yelda Dere, Yuksel Kucukzeybek, Mustafa Oktay Tarhan, Sadi Bener, Kadriye Bahriye Payzin, Betul Bolat Kucukzeybek, Fusun Ozdemirkiran |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Microbiology (medical) Oncology medicine.medical_specialty bone marrow Anemia Biopsy lcsh:QR1-502 thrombocytopenia Gastroenterology lcsh:Microbiology Pathology and Forensic Medicine Metastasis neoplasm metastasis Breast cancer Internal medicine Pathology medicine Carcinoma lcsh:Pathology Humans Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry Cancer General Medicine Middle Aged Prognosis medicine.disease Primary tumor Treatment Outcome medicine.anatomical_structure Female Bone marrow business lcsh:RB1-214 |
| Zdroj: | Indian Journal of Pathology and Microbiology, Vol 57, Iss 3, Pp 396-399 (2014) |
| ISSN: | 0377-4929 |
| Popis: | Background: Bone marrow biopsy is widely used method for diagnosis, follow-up and staging of hemato-oncologic diseases. This procedure is also used for determining the bone marrow metastasis in patients with solid tumors. In this study, clinical, hematological, and pathological features of 58 patients with bone marrow metastases diagnosed by bone marrow biopsies were examined retrospectively Materials and Methods: Among 3345 bone marrow biopsies performed in our hospital between January 2006 and August 2013, 58 cases with solid tumor metastasized to bone marrow were included in this study. Results: Among 58 cases with solid organ carcinoma metastasis in bone marrow, mean age was 59.9. Thirty-nine cases were found to have a known primary tumor focus. The most common tumors metastasized to bone marrow were breast carcinomas (23 patients, 59%), gastric carcinomas (6 patients, 15.3%), prostate carcinomas (4 patients, 10,2%), and lung carcinomas (3 patients, 7.7%), respectively. Nineteen patients were firstly diagnosed from bone marrow biopsies as metastatic carcinomas. The median overall survival after bone marrow metastasis was 28 days (95% confidence interval: 7.5-48.4). The median overall survival difference was not statistically significant between patients with primary known and unknown tumor (P = 0.973). Statistically significant difference was observed between the survival of breast cancer and gastric cancer (P = 0.028). The most common hematologic symptom was the coexistence of anemia and thrombocytopenia (31%), thrombocytopenia (27.6%) and anemia (20.7%) alone. The median overall survival difference was statistically significant between patients who have anemia and thrombocytopenia (P < 0.005). Conclusion: Bone marrow biopsy is an easily accessible, easily applied, a useful procedure for diagnosing metastatic diseases in patients with hematologic symptoms such as anemia and thrombocytopenia besides being an uncomfortable procedure for patients. Furthermore, it is useful in predicting the prognosis and short survey after diagnosing bone marrow metastasis. |
| Databáze: | OpenAIRE |
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