Sodium oxybate in narcolepsy with cataplexy: Zurich sleep center experience
| Autor: | Sonja Tartarotti, Ulf Kallweit, Esther Werth, Christian R. Baumann, Ramin Khatami, Rositsa Poryazova, Philipp O. Valko, Claudio L. Bassetti |
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| Přispěvatelé: | University of Zurich |
| Rok vydání: | 2010 |
| Předmět: |
Multiple Sleep Latency Test
Adult Male Cataplexy Adolescent Polysomnography Excessive daytime sleepiness 610 Medicine & health medicine Humans Aged Narcolepsy medicine.diagnostic_test business.industry Epworth Sleepiness Scale Actigraphy Middle Aged medicine.disease 10040 Clinic for Neurology 2728 Neurology (clinical) Treatment Outcome Neurology 2808 Neurology Anesthesia Female Neurology (clinical) medicine.symptom business Sodium Oxybate Sleep paralysis |
| Zdroj: | European neurology. 65(3) |
| ISSN: | 1421-9913 |
| Popis: | Sodium oxybate (SO; Xyrem®) has been approved in most countries for treatment of narcolepsy and cataplexy. In this study, we present a single-center experience of a series of 18 patients with narcolepsy with cataplexy (18/18 DQB1*0602 positive, 17/17 with low/absent cerebrospinal fluid hypocretin) in whom SO was prescribed. After 26 ± 13 months, 13/18 patients were still on SO at a mean dosage of 6.1 ± 1.2 g (in 8 of them in combination with stimulants). The following significant effects were observed: improved subjective sleepiness (12/13), cataplexy (13/13; median number of attacks from 20 to 1/month), hallucinations (8/10) and sleep paralysis (8/8); increase in mean sleep latency on the Maintenance of Wakefulness Test (from 5.5 to 17.4 min) and sleep/rest efficiency on actigraphy (from 61 to 76%); decrease in Epworth Sleepiness Scale score (from 18 to 14), sleep onset REM periods on the Multiple Sleep Latency Test (from 3.6 to 2.4) and errors in the Steer-Clear Test (from 11 to 2%). Five patients discontinued SO because of insufficient compliance (n = 2), lack of efficiency (n = 1) and side effects (n = 1). These data confirm and expand previous reports on the good effects and tolerability of SO as a treatment for narcolepsy with cataplexy. |
| Databáze: | OpenAIRE |
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