Association between maternal and infant class I and II HLA alleles and of their concordance with the risk of perinatal HIV type 1 transmission
| Autor: | John P. A. Ioannidis, Steven M. Wolinsky, Henry A. Elrich, Robert Winchester, Christos Ntais, Bette T. Korber, Anastasia Polycarpou, Paul Krogstad, Sarah Rowland-Jones, Arthur J. Ammann, T Rostron |
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| Rok vydání: | 2016 |
| Předmět: |
Risk
Infectious Disease Transmission Vertical Concordance Genes MHC Class II Immunology Population Genes MHC Class I Human leukocyte antigen Hiv-1 Acquired immunodeficiency syndrome (AIDS) Pregnancy Virology Genotype medicine Humans Allele education Alleles Acquired Immunodeficiency Syndrome education.field_of_study biology business.industry Acquired Immunodeficiency Syndrome/drug therapy/*transmission/virology Infant Newborn Viral Load medicine.disease biology.organism_classification Infectious Diseases Lentivirus HIV-1 Female Viral disease business |
| Popis: | We aimed to investigate the influence of class I and class II HLA specificities and of the concordance between maternal and infant HLA on vertical HIV-1 transmission. HLA typing of samples from mothers and infants enrolled in the Ariel study, a perinatal HIV-1 transmission cohort including 203 mother-infant pairs, was performed by serological and molecular methods. HLA effects were evaluated alone and by multivariate modeling considering also other known predictors of perinatal HIV-1 transmission (maternal viral load, antiretroviral therapy, duration of rupture of membranes, and histological chorioamnionitis). Modest associations were seen with specific HLA markers (increased risk with infant B67 and B58 and maternal DR1; decreased risk with maternal B12), but these were not statistically significant after adjusting for multiple comparisons. Mother-infant concordance at any class I locus was a strong predictor of transmission (odds ratio [OR], 4.16; p = 0.028). Transmission was not associated with class II concordance. Class I HLA concordance retained its importance after adjusting for maternal viral load, antiretroviral therapy, duration of rupture of membranes or histological chorioamnionitis. In multivariate modeling, only class I concordance (OR, 3.59; p = 0.069) and chorioamnionitis (OR, 3.79; p = 0.030) were retained as independent predictors of transmission. HLA alleles, and in particular the class I concordance between maternal and neonatal HLA, may regulate the risk of perinatal HIV-1 transmission. AIDS Res Hum Retroviruses |
| Databáze: | OpenAIRE |
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