Anti-Dopamine Receptor 2 Antibody-Positive Encephalitis in Adolescent
| Autor: | Xuejiao Dai, Lilu Kuang, Li Feng, Xiaoping Yi, Weiting Tang, Qiao Liao, Xiaoyan Long, Junling Wang, Jing Li, Huan Yang, Bo Xiao, Guoliang Li, Si Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Movement disorders Case Report Striatum Nucleus accumbens lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Dopamine receptor D2 Basal ganglia medicine basal ganglia encephalitis lcsh:Neurology. Diseases of the nervous system D2R business.industry Olfactory tubercle medicine.disease 030104 developmental biology Neurology psychiatric Dopamine receptor adolescent Neurology (clinical) movement disorder medicine.symptom business 030217 neurology & neurosurgery Encephalitis |
| Zdroj: | Frontiers in Neurology, Vol 11 (2020) Frontiers in Neurology |
| ISSN: | 1664-2295 |
| Popis: | Autoimmune encephalitic syndromes include mutism, somnolence, movement disorder, and behavioral, or psychiatric symptoms. When paired with bilateral basal ganglia lesions on magnetic resonance imaging, these support the diagnosis of basal ganglia encephalitis (BGE). BGE is a rare but distinct entity of putative autoimmune etiology, with specific basal ganglia inflammation and acute movement disorders. A previous study identified dopamine-2 receptors (D2R) antibody to be positive in most BGE children, indicating that the D2R antibody may trigger the downstream pathological process in BGE patients. The highest levels of D2R are found in the striatum, the nucleus accumbens, and the olfactory tubercle. D2R antibody-positive BGE is widely reported in children. Here we present a 17-year-old girl with a typical clinical feature of basal ganglia encephalitis, who benefited from immune therapy. |
| Databáze: | OpenAIRE |
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