Implantable cardiac defibrillator events in patients with arrhythmogenic right ventricular cardiomyopathy
| Autor: | Łukasz Szumowski, Alicja Cicha-Mikołajczyk, Elżbieta Katarzyna Biernacka, Piotr Hoffman, Olgierd Woźniak, Karolina Borowiec, Marek Konka, Krzysztof Bernard Poślednik, Andrzej Przybylski |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Population Ventricular tachycardia Right ventricular cardiomyopathy Sudden cardiac death Internal medicine medicine Humans education Arrhythmogenic Right Ventricular Dysplasia Heart transplantation education.field_of_study business.industry medicine.disease Arrhythmogenic right ventricular dysplasia Defibrillators Implantable Death Sudden Cardiac Ventricular fibrillation Cardiology Antitachycardia Pacing Tachycardia Ventricular Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Heart (British Cardiac Society). 108(1) |
| ISSN: | 1468-201X |
| Popis: | ObjectiveArrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with a risk of sudden cardiac death. Optimal risk stratification is still under debate. The main purpose of this long-term, single-centre observation was to analyse predictors of appropriate and inappropriate implantable cardioverter-defibrillator (ICD) interventions in the population of patients with ARVC with a high risk of life-threatening arrhythmias.MethodsThe study comprised 65 adult patients (median age 40 years, 48 men) with a definite diagnosis of ARVC who received ICD over a time span of 20 years in primary (40%) or secondary (60%) prevention of sudden cardiac death. The study endpoints were first appropriate and inappropriate ICD interventions (shock or antitachycardia pacing) after device implantation.ResultsDuring a median follow-up of 7.75 years after ICD implantation, nine patients died and six individuals underwent heart transplantation. Appropriate ICD interventions occurred in 43 patients (66.2%) and inappropriate ICD interventions in 18 patients (27.7%). Multivariable analysis using cause-specific hazard model identified three predictors of appropriate ICD interventions: right ventricle dysfunction (cause-specific HR 2.85, 95% CI 1.56 to 5.21, pConclusionsRight ventricle dysfunction, age |
| Databáze: | OpenAIRE |
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