Comparative immune responses against Psoroptes ovis in two cattle breeds with different susceptibility to mange
| Autor: | Rika Grit, Ana González-Hernández, Korneel Grauwet, Koen Chiers, Wim Van den Broeck, Peter Geldhof, Stefanie Van Coppernolle, Frederik Van Meulder, Charlotte Sarre, Edwin Claerebout |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Mite Infestations
[SDV]Life Sciences [q-bio] 030231 tropical medicine PATHOGENESIS Mange Cattle Diseases Breeding Beef cattle DENDRITIC CELLS IMMUNOLOGY STANCHIONED CATTLE 03 medical and health sciences 0302 clinical medicine Immune system SARCOPTES-SCABIEI Belgium Antigen Immunity medicine Animals Ovis 030304 developmental biology 2. Zero hunger Immunity Cellular 0303 health sciences Innate immune system General Veterinary biology INDUCTION Psoroptidae Biology and Life Sciences SHEEP SCAB MITE INFESTATION medicine.disease biology.organism_classification veterinary(all) Up-Regulation Immunology Psoroptes ovis Leukocytes Mononuclear Cytokines Cattle Female Disease Susceptibility CALVES RESISTANCE Research Article |
| Zdroj: | VETERINARY RESEARCH Veterinary Research Veterinary Research, BioMed Central, 2015, 46 (1), pp.131. ⟨10.1186/s13567-015-0277-x⟩ |
| ISSN: | 0928-4249 1297-9716 |
| DOI: | 10.1186/s13567-015-0277-x⟩ |
| Popis: | International audience; AbstractThe sheep scab mite, Psoroptes ovis, is a major problem in the beef cattle industry, especially in Belgian Blue (BB) cattle. This breed is naturally more predisposed to psoroptic mange but reasons for this high susceptibility remain unknown. Different immune responses could be a potential cause; thus in this study, the cutaneous immune response and in vitro cellular immune response after antigen re-stimulation were examined in naturally infested BB. Cytokine production in the skin and in circulating re-stimulated peripheral blood mononuclear cells (PBMC) demonstrated a mixed pro-inflammatory Th2/Th17 profile, with transcription of IL-4, IL-13, IL-6 and IL-17. Strong IL-17 up-regulation in the skin of BB was associated with an influx of eosinophils and other immune cells, potentially leading towards more severe symptoms. Virtually no changes in cutaneous IFN-γ transcription were detected, while there was substantial IFN-γ up-regulation in re-stimulated PBMC from infested and uninfested animals, potentially indicating a role of this pro-inflammatory cytokine in the innate immune response. In Holstein–Friesian (HF) cattle, generally more resistant to P. ovis infection, a largely similar immunologic response was observed. Differences between HF and BB were the lack of cutaneous IL-17 response in infested HF and low transcription levels of IFN-γ and high IL-10 transcription in re-stimulated PBMC from both infested and uninfested animals. Further research is needed to identify potential cell sources and biological functions for these cytokines and to fully unravel the basis of this different breed susceptibility to P. ovis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink