Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways
| Autor: | Ramakrishna Sistla, Mahesh Kumar Jerald, Sateesh Alavala, Nasiruddin Nalban, Rajendra Sangaraju |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine NF-E2-Related Factor 2 medicine.medical_treatment Immunology Anti-Inflammatory Agents Down-Regulation Dermatitis Inflammation Pharmacology Antioxidants Proinflammatory cytokine Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Psoriasis Animals Immunology and Allergy Medicine Peroxidase Flavonoids Mice Inbred BALB C Imiquimod business.industry Body Weight NF-kappa B Membrane Proteins NF-κB medicine.disease Galangin Disease Models Animal Oxidative Stress 030104 developmental biology Cytokine chemistry 030220 oncology & carcinogenesis Cytokines Tumor necrosis factor alpha medicine.symptom business Heme Oxygenase-1 Spleen Signal Transduction |
| Zdroj: | International Immunopharmacology. 96:107754 |
| ISSN: | 1567-5769 |
| Popis: | Psoriasis is a most common chronic autoimmune-arbitrated cutaneous inflammatory skin disorder by unclear pathogenesis. In this current study we demonstrated the effect of galangin (GAL) on imiquimod (IMQ)-induced psoriasis-like skin inflammation and decipher its possible protective mechanism which has not been investigated. The in vivo results revealed that GAL at 1% w/w and 2% w/w for six consecutive days markedly reduced IMQ-induced PASI scoring, skin, ear thickness, hematological markers, levels of nitrites, TBARS, MPO, histopathological, as well modulated the protein levels of pro-inflammatory mediators of COX-2, iNOS, NF-κB pathway and pro-inflammatory cytokines IL-17, IL-23, IL-1β in the skin and also IL-6, TNF-α in both skin and serum. Besides, GAL restored the levels of antioxidants markers such as SOD, CAT, GST, GSH, GR and Vit-C, anti-inflammatory cytokine of IL-10, and the protein levels of Nrf2/HO-1 in the skin compared to the IMQ group. Finally, our study demonstrates that GAL exerted its protective effect by up-regulating the anti-inflammatory and the antioxidant markers against psoriasis pre-clinical models indicating its potency for treating psoriasis in humans. |
| Databáze: | OpenAIRE |
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