Transcallosal conduction in paroxysmal kinesigenic dyskinesia
| Autor: | Tayfun Kasikci, Yasar Kutukcu, Mehmet Yücel, Semai Bek, Zeki Odabasi, Güray Koç |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Physiology medicine.medical_treatment Inhibitory postsynaptic potential 050105 experimental psychology Functional Laterality Statistics Nonparametric Corpus Callosum 03 medical and health sciences Young Adult 0302 clinical medicine otorhinolaryngologic diseases medicine Reaction Time Humans 0501 psychology and cognitive sciences business.industry Electromyography 05 social sciences Neural Inhibition Paroxysmal dyskinesia musculoskeletal system Evoked Potentials Motor Transcranial Magnetic Stimulation Sensory Systems Transcranial magnetic stimulation Dystonia cardiovascular system Excitatory postsynaptic potential Silent period Female business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Somatosensorymotor research. 34(4) |
| ISSN: | 1369-1651 |
| Popis: | Detecting whether a possible disequilibrium between the excitatory and inhibitory interhemispheric interactions in paroxysmal kinesigenic dyskinesia (PKD) exists.This study assessed measures of motor threshold, motor evoked potential latency, the cortical silent period, the ipsilateral silent period and the transcallosal conduction time (TCT) in PKD patients. Data were compared between the clinically affected hemisphere (aH) and the fellow hemisphere (fH).The transcallosal conduction time from the aH to the fH was 11.8 ms (range = 2.3-20.7) and 13.6 ms (range = 2.8-67.7) from the fH to the aH. The difference in TCT in the affected side was significant (p = .019).The findings demonstrated that, although inhibitory interneurons act normally and symmetrically between the motor cortices and transcallosal inhibition was normal and symmetrical between both sides, the onset of transcallosal inhibition was asymmetrical. The affected hemisphere's inhibition toward the unaffected hemisphere is faster compared to the inhibition provided by the fellow hemisphere. These results are consistent with an inhibitory deficit in the level of interhemispheric interactions.This study revealed a defect in inhibition of the motor axis could be responsible in the pathological mechanisms of kinesigenic dyskinesia. |
| Databáze: | OpenAIRE |
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