Cell cycle markers and apoptotic proteins in oral tongue squamous cell carcinoma in young and elderly patients
| Autor: | Aline Carvalho Batista, Luan Éverton Galdino Barnabé, Elismauro Francisco Mendonça, Pollianna Muniz Alves, Cassiano Francisco Weege Nonaka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Apoptosis Malignancy Gastroenterology Statistics Nonparametric 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Carcinoma medicine Biomarkers Tumor Humans General Materials Science 030212 general & internal medicine Stage (cooking) Young adult Cyclin-Dependent Kinase Inhibitor p16 Aged bcl-2-Associated X Protein biology business.industry Cell Cycle Age Factors RK1-715 030206 dentistry Cell cycle Middle Aged medicine.disease Immunohistochemistry Tongue Neoplasms Tumor Burden Dentistry biology.protein Carcinoma Squamous Cell Female Antibody Tumor Suppressor Protein p53 business Apoptosis Regulatory Proteins |
| Zdroj: | Brazilian Oral Research, Vol 33 (2019) Brazilian Oral Research v.33 2019 Brazilian Oral Research Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO Brazilian Oral Research, Volume: 33, Article number: e103, Published: 25 NOV 2019 |
| ISSN: | 1807-3107 |
| Popis: | The immunoexpression of p16, p53, and Bax in oral tongue squamous cell carcinoma (OTSCC) in young and elderly patients is assessed based on clinical and morphological parameters. The sample consists of 60 OTSCC cases: 30 in young (age ≤ 45 years) and 30 in elderly (age ≥ 60 years) patients. Clinical (tumor size, regional node metastasis, distant metastasis, and clinical stage) and morphological (histological grade of malignancy) parameters were evaluated. Immunohistochemical quantitative analysis was performed using anti-p16, anti-p53, and anti-Bax antibodies. None of the evaluated proteins exhibited statistically significant differences between young and elderly patients (p>0.05). There was a significant association of p16 immunoexpression with clinical parameters in elderly patients. There were no associations of p53 and Bax with any of the clinico-morphological parameters. Correlations between p16 and Bax and between p53 and Bax immunoexpression were observed in young patients (r = 0.363; p = 0.048) and in elderly patients (r = 0.433; p = 0.017), respectively. In conclusion, the assessed proteins could not be used to determine differences in the biological behavior of OTSCC between young and elderly patients. Therefore, all proteins activated the pro-apoptotic pathway of OTSCC in both groups. |
| Databáze: | OpenAIRE |
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