Effects of Air Transportation Cause Physiological and Biochemical Changes Indicative of Stress Leading to Regulation of Chaperone Expression Levels and Corticosterone Concentration
| Autor: | Seungwan Jee, Eon-Pil Lee, SeHyun Lee, Jae Ho Lee, Dae Youn Hwang, Changjoon Bae, Jong-Min Woo, Young Jin Jung, Sunbo Shim, Hong-Sung Kim, Suhae Lee, Hae-Wook Choi, Byoungguk Kim, Kabryong Chae, JungSik Cho, Chuelkyu Kim, Byung-Wook Cho, Jisoon Sin |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Aircraft F344 rats General Biochemistry Genetics and Molecular Biology Toxicology chemistry.chemical_compound Recovery period Sex Factors Corticosterone Internal medicine medicine Animals HSP70 Heat-Shock Proteins Endoplasmic Reticulum Chaperone BiP Group level Heat-Shock Proteins Behavior Animal General Veterinary biology General Medicine Rats Inbred F344 Rats Hsp70 Endocrinology chemistry Chaperone (protein) Aerospace Medicine biology.protein Tissue type Female Animal Science and Zoology Stress Psychological Molecular Chaperones Hormone |
| Zdroj: | Experimental Animals. 58:11-17 |
| ISSN: | 1881-7122 1341-1357 |
| Popis: | Laboratory animals generally experience numerous unfamiliar environmental and psychological influences such as noises, temperatures, handling, shaking, and smells during the process of air transportation. To investigate whether stress induced by air transportation affects stress-related factors in animals, the levels of hormone and chaperone protein were measured in several tissues of F344 rats transported for 13 h and not transported. Herein, we conclude that the levels of corticosterone, HSP70, and GRP78 were significantly increased in the transported group compare to not transported group, but they were rapidly restored to the not transported group level after a recovery period of one week. However, the magnitude of induction and restoration levels of these factors varied depending on the tissue type. Thus, these results suggest that air transportation should be considered for the improvement of laboratory animal health and to reduce the incidence of laboratory animal stress. |
| Databáze: | OpenAIRE |
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