STAT3-regulated LncRNA LINC00160 mediates cell proliferation and cell metabolism of prostate cancer cells by repressing RCAN1 expression

Autor:	Wenjing Zhu, Dongya Sheng, Yiqun Shao, Qiang Zhang, Yu Peng
Rok vydání:	2022
Předmět:	Male STAT3 Transcription Factor Clinical Biochemistry Muscle Proteins Prostatic Neoplasms Cell Biology General Medicine Neoplasm Proteins DNA-Binding Proteins Gene Expression Regulation Neoplastic PC-3 Cells Humans RNA Long Noncoding RNA Neoplasm Molecular Biology Cell Proliferation
Zdroj:	Molecular and Cellular Biochemistry. 477:865-875
ISSN:	1573-4919 0300-8177
DOI:	10.1007/s11010-021-04284-1
Popis:	Long non-coding RNA (LncRNA) LINC00160 was reported to be associated with cancer progression and mediates drug resistance. However, the role of LINC00160 in prostate cancer remains unclear. The study sought to study the function of LINC00160 in prostate cancer. Moreover, the potential mechanism was investigated. Silence of LINC00160 inhibited proliferation and promoted the apoptosis of prostate cancer cells, retarded the glycolysis of prostate cancer cells. By acting as a transcription activator, STAT3 induced LINC00160 expression, which regulated RCAN1 transcription epigenetically via binding to EZH2. Mechanically, LINC00160 mediated prostate cell proliferation and metabolism by repressing RCAN1 expression. In summary, LINC00160 may function as the novel marker for prostate cancer diagnosis and therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1c4055a95c3be516622d26900a4a53 https://doi.org/10.1007/s11010-021-04284-1 Zobrazit plný text záznamu Full text from SpringerLink