Interleukin-6 levels in umbilical artery serum in normal and abnormal pregnancies
| Autor: | P Anastasiadis, K. Giagloglou, George Galazios, G. Vassaras, Efstratios Maltezos, Dimitrios Papazoglou |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Population Gestational Age Umbilical Arteries Preeclampsia Obstetric Labor Premature Pre-Eclampsia Predictive Value of Tests Pregnancy medicine.artery Blood plasma medicine Birth Weight Humans education Interleukin 6 Preterm delivery Gynecology education.field_of_study biology Obstetrics business.industry Interleukin-6 Pregnancy Outcome Obstetrics and Gynecology Umbilical artery General Medicine medicine.disease Fetal Blood Pregnancy Complications biology.protein Gestation Female business Maternal Age |
| Zdroj: | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 78(2) |
| ISSN: | 0020-7292 |
| Popis: | The aim of our study was to determine the correlation of abnormal umbilical artery interleukin-6 levels with pregnancies complicated by preterm delivery and pre-eclampsia.Cord serum (umbilical artery) was collected at delivery by cesarean section or spontaneous delivery. Samples were retrieved from patients with normal and abnormal pregnancies. Patients were divided into three groups: group 1, a control group of samples from uncomplicated pregnancies (n = 24); group 2, patients with pre-eclampsia (n = 21); and group 3, patients having had preterm delivery (n = 29). Interleukin-6 was measured by bioassays. Statistics were performed with the Mann-Whitney U-, Student's t- and the Kruskal-Wallis tests.Interleukin-6 levels in women with preterm delivery were statistically higher compared to those of normal pregnancies (P0.05) and lower in the cord serum of pre-eclamptic when compared to those of normal pregnancies (P0.05).In conclusion, we believe that further investigations could elucidate the role of this pleiotropic cytokine in both, normal and pathologic reproductive biology, and determine the clinical utility of IL-6 measurements in obstetric practice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text