Pre-emptive effect of dexamethasone and methylprednisolone on pain, swelling, and trismus after third molar surgery: a split-mouth randomized triple-blind clinical trial
| Autor: | Fernanda Oliveira-Ferreira, Saulo Gabriel Moreira Falci, Carlos Eduardo Pinto Alcântara, Marcos Luciano Pimenta Pinheiro, Cássio Roberto Rocha dos Santos |
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| Rok vydání: | 2012 |
| Předmět: |
Molar
Adult Male medicine.medical_specialty Adolescent Visual analogue scale Anti-Inflammatory Agents Trismus Methylprednisolone Dexamethasone Third molar surgery Medicine Edema Humans Pain Measurement Pain Postoperative business.industry Tooth Impacted Surgery Clinical trial Treatment Outcome Otorhinolaryngology Anesthesia Tooth Extraction Female Molar Third Oral Surgery medicine.symptom Swelling business medicine.drug |
| Zdroj: | International journal of oral and maxillofacial surgery. 43(1) |
| ISSN: | 1399-0020 |
| Popis: | The aim of this study was to compare the effect of dexamethasone 8 mg and methylprednisolone 40 mg for the control of pain, swelling, and trismus following the extraction of impacted third molars. Sixteen healthy patients with a mean age of 20.3 (standard deviation 1.25) years received a single oral dose of either drug 1 h prior to each surgical procedure (left and right teeth). At 24, 48, and 72 h and 7 days following surgery, swelling was determined using linear measurements on the face and trismus was determined by maximal mouth opening. Postoperative pain was self-recorded by the patients using a visual analogue scale at 8-h intervals for a period of 72 h. Data analysis involved descriptive statistics and the Wilcoxon, and paired t tests (P < 0.05). Dexamethasone controlled swelling better than methylprednisolone at all postoperative evaluations (P < 0.02) and led to greater mouth opening 48 h after surgery (P = 0.029). No statistically significant difference was found between drugs with regard to pain. In conclusion, pre-emptive dexamethasone 8 mg demonstrated better control of swelling and limited mouth opening in comparison to methylprednisolone 40 mg, with no differences between drugs regarding pain control. |
| Databáze: | OpenAIRE |
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