Ciliary neurotrophic factor arrests muscle and motoneuron degeneration in androgen-insensitive rats
| Autor: | Vivien Wong, Nancy G. Forger, Breedlove Sm |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty X Chromosome medicine.drug_class Genetic Linkage Neuromuscular Junction Nerve Tissue Proteins Biology Ciliary neurotrophic factor Rats Mutant Strains Rats Sprague-Dawley Cellular and Molecular Neuroscience Bulbocavernosus reflex Neurotrophic factors Internal medicine medicine Animals Ciliary Neurotrophic Factor Nerve Growth Factors Testicular feminization Motor Neurons General Neuroscience Androgen Rats Androgen receptor Endocrinology Levator ani Phenotype Receptors Androgen Nerve Degeneration biology.protein Female Hormone Penis |
| Zdroj: | Journal of neurobiology. 28(3) |
| ISSN: | 0022-3034 |
| Popis: | Steroid hormones and neurotrophic factors exert profound and widespread effects on the developing nervous system, including regulation of the size, connectivity, and survival of neurons. Androgenic control of the survival of motoneurons in the spinal nucleus of the bulbocavernosus (SNB) of rats has been well documented. We previously found that ciliary neurotrophic factor (CNTF) mimics many effects of androgen on the developing SNB. Whether effects of CNTF depend on the presence of a functional androgen receptor was evaluated in the present study. Androgen-insensitive male rats bearing the testicular feminization mutation, Tfm, and female litter-mates were treated with CNTF or with vehicle alone from embryonic day 22 through postnatal day 3. On postnatal day 4 SNB cell number was elevated in both groups receiving CNTF. Volumes of the bulbocavernosus (BC) and levator ani (LA) muscles, targets of SNB motoneurons, were also markedly increased by CNTF. Since the BC appears to degenerate completely in untreated females, these results indicate that CNTF can delay or prevent muscle fiber death. The relative sparing of muscles and motoneurons did not differ for Tfm males and females, demonstrating that effects of CNTF on the SNB neuromuscular system do not require functional androgen receptors. |
| Databáze: | OpenAIRE |
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