Resveratrol protects against cisplatin-induced ovarian and uterine toxicity in female rats by attenuating oxidative stress, inflammation and apoptosis
| Autor: | Ahmed Abd-Eltawab Tammam, Noha M Abd El-Fadeal, Alaa Abdelhamid Mohamed, Mina T Kelleni, Mahrous A. Ibrahim, Farooq Ahmed Wani, Mohammed Ubaidullah Sayeed, Ibrahim A. Albahlol |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Uterus Nitric Oxide Synthase Type II Apoptosis Pharmacology Resveratrol Toxicology medicine.disease_cause Antioxidants Protein Carbonylation chemistry.chemical_compound 0302 clinical medicine Malondialdehyde Progesterone bcl-2-Associated X Protein Estradiol NF-kappa B General Medicine Catalase Glutathione medicine.anatomical_structure 030220 oncology & carcinogenesis Toxicity Cytokines Female Reproductive toxicity medicine.drug Ovary Protective Agents Models Biological 03 medical and health sciences medicine Animals Rats Wistar Cisplatin Inflammation Glutathione Peroxidase business.industry Superoxide Dismutase Prolactin Oxidative Stress 030104 developmental biology chemistry Cyclooxygenase 2 Follicle Stimulating Hormone business Oxidative stress Biomarkers |
| Zdroj: | Chemico-biological interactions. 338 |
| ISSN: | 1872-7786 |
| Popis: | Cisplatin is an important antineoplastic drug used in multiple chemotherapeutic regimens but unfortunately causes serious toxic effects as ovarian and uterine toxicity. This study aimed to investigate the potential protective effect of resveratrol (RSV) against cisplatin-induced ovarian and uterine toxicity in female rats. Thirty-two female Wistar rats were divided randomly into four groups (n = 8 in each). Control group received oral normal saline for 28 days; RSV group received RSV (10 mg/kg; daily) via oral gavage; CIS group received a single dose of CIS (7 mg/kg; i.p.) on the 21st day; (CIS + RSV) group received both RSV and CIS by the same schedules and doses of RSV and CIS groups, respectively. Results demonstrated a significant decrease in MDA level and a significant increase in both glutathione content and activity of the antioxidant enzymes GPx, SOD, and CAT in the tissues of the ovary and uterus of CIS + RSV group in comparison to that of CIS group (P |
| Databáze: | OpenAIRE |
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