The TrkB‐T1 receptor mediates BDNF‐induced migration of aged cardiac microvascular endothelial cells by recruiting Willin

Autor:	Li Yanmei, Nianjue Zheng, Chen Yilin, Xuwei Chen, Xufeng Qi, Xiaotao Shen, Lilin Li, Xu Ganlin, Hui Zhao, Ziqiang Yuan, Wensheng Chen, Dongqing Cai, Zhefeng Wang, Xin Zheng
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	0301 basic medicine Gene isoform Aging Angiogenesis Hippo pathway Neovascularization Physiologic Biology migration cardiac microvascular endothelial cell aging 03 medical and health sciences 0302 clinical medicine Willin/FRMD6 Cell Movement Animals Humans Receptor trkB Myocytes Cardiac Receptor Cells Cultured Cellular Senescence BDNF–TrkB Hippo signaling pathway Mechanism (biology) Effector musculoskeletal neural and ocular physiology Brain-Derived Neurotrophic Factor Intracellular Signaling Peptides and Proteins Endothelial Cells Cell Biology Phenotype Cell biology Rats 030104 developmental biology HEK293 Cells nervous system Trk receptor embryonic structures Original Article 030217 neurology & neurosurgery Signal Transduction
Zdroj:	Aging Cell
ISSN:	1474-9726 1474-9718
Popis:	The mechanism of age‐related decline in the angiogenic potential of the myocardium is not yet fully understood. Our previous report revealed that the aging of cardiac microvascular endothelial cells (CMECs) led to changes in their expression of receptor Trk isoforms: among the three isoforms (TrkB‐FL, TrkB‐T1 and TrkB‐T2), only the truncated TrkB‐T1 isoform continued to be expressed in aged CMECs, which led to decreased migration of CMECs in aging hearts. Thus far, how BDNF induces signalling through the truncated TrkB‐T1 isoform in aged CMECs remains unclear. Here, we first demonstrated that aged CMECs utilize BDNF–TrkB‐T1 signalling to recruit Willin as a downstream effector to further activate the Hippo pathway, which then promotes migration. These findings suggest that the aging process shifts the phenotype of aged CMECs that express TrkB‐T1 receptors by transducing BDNF signals via the BDNF–TrkB‐T1–Willin–Hippo pathway and that this change might be an important mechanism and therapeutic target of the dysfunctional cardiac angiogenesis observed in aged hearts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f11abd6c807a470a4a827ae218ea75a http://europepmc.org/articles/PMC6413668 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.